PLRG1 (pleiotropic regulator 1)

2014-11-01  

Identity

HGNC
PLRG1
LOCATION
4q31.3
LOCUSID
5356
ALIAS
Cwc1,PRL1,PRP46,PRPF46,TANGO4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5356
MIM: 605961
HGNC: 9089
Ensembl: ENSG00000171566

Variants:

dbSNP: 5356
ClinVar: 5356
TCGA: ENSG00000171566
COSMIC: PLRG1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000171566ENST00000302078O43660
ENSG00000171566ENST00000499023O43660
ENSG00000171566ENST00000503251H0YAA2
ENSG00000171566ENST00000504341D6RA26
ENSG00000171566ENST00000506192B7Z982
ENSG00000171566ENST00000506627H0YA24
ENSG00000171566ENST00000509975D6RE04

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
SpliceosomeKEGGko03040
SpliceosomeKEGGhsa03040
Spliceosome, Prp19/CDC5L complexKEGGhsa_M00353
Spliceosome, 35S U5-snRNPKEGGhsa_M00355
Spliceosome, Prp19/CDC5L complexKEGGM00353
Spliceosome, 35S U5-snRNPKEGGM00355
Gene ExpressionREACTOMER-HSA-74160
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA SplicingREACTOMER-HSA-72172
mRNA Splicing - Major PathwayREACTOMER-HSA-72163

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
352904362022RNA Helicase DHX37 Facilitates Liver Cancer Progression by Cooperating with PLRG1 to Drive Superenhancer-Mediated Transcription of Cyclin D1.8
352904362022RNA Helicase DHX37 Facilitates Liver Cancer Progression by Cooperating with PLRG1 to Drive Superenhancer-Mediated Transcription of Cyclin D1.8
332391702021Crystal structure of the WD40 domain of human PLRG1.0
332391702021Crystal structure of the WD40 domain of human PLRG1.0
204674372010Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.38
204674372010Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.38
145762972003Identification of peptide inhibitors of pre-mRNA splicing derived from the essential interaction domains of CDC5L and PLRG1.11
145762972003Identification of peptide inhibitors of pre-mRNA splicing derived from the essential interaction domains of CDC5L and PLRG1.11
97652071998Pleiotropic control of glucose and hormone responses by PRL1, a nuclear WD protein, in Arabidopsis.88
97652071998Pleiotropic control of glucose and hormone responses by PRL1, a nuclear WD protein, in Arabidopsis.88

Citation

Dessen P

PLRG1 (pleiotropic regulator 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/72004/plrg1-(pleiotropic-regulator-1)