PMCH (pro-melanin concentrating hormone)

2014-11-01  

Identity

HGNC
LOCATION
12q23.2
LOCUSID
ALIAS
MCH,ppMCH

Other Information

Locus ID:

NCBI: 5367
MIM: 176795
HGNC: 9109
Ensembl: ENSG00000183395

Variants:

dbSNP: 5367
ClinVar: 5367
TCGA: ENSG00000183395
COSMIC: PMCH

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000183395ENST00000329406P20382

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA447216SchizophreniaDiseaseClinicalAnnotationassociatedPD17541984
PA450688olanzapineChemicalClinicalAnnotationassociatedPD17541984

References

Pubmed IDYearTitleCitations
380516702024Melanin-Concentrating Hormone Is Associated With Delayed Neurocognitive Recovery in Older Adult Patients With Preoperative Sleep Disorders Undergoing Spinal Anesthesia.0
380516702024Melanin-Concentrating Hormone Is Associated With Delayed Neurocognitive Recovery in Older Adult Patients With Preoperative Sleep Disorders Undergoing Spinal Anesthesia.0
333705672021Melanin-concentrating hormone and food intake control: Sites of action, peptide interactions, and appetition.16
333705672021Melanin-concentrating hormone and food intake control: Sites of action, peptide interactions, and appetition.16
234629902013Human hypocretin and melanin-concentrating hormone levels are linked to emotion and social interaction.111
236675822013Cerebrospinal fluid melanin-concentrating hormone (MCH) and hypocretin-1 (HCRT-1, orexin-A) in Alzheimer's disease.23
238848612013The roles of melanin-concentrating hormone in energy balance and reproductive function: Are they connected?15
234629902013Human hypocretin and melanin-concentrating hormone levels are linked to emotion and social interaction.111
236675822013Cerebrospinal fluid melanin-concentrating hormone (MCH) and hypocretin-1 (HCRT-1, orexin-A) in Alzheimer's disease.23
238848612013The roles of melanin-concentrating hormone in energy balance and reproductive function: Are they connected?15
222959722012Interleukin-6 receptor α is co-localised with melanin-concentrating hormone in human and mouse hypothalamus.14
222959722012Interleukin-6 receptor α is co-localised with melanin-concentrating hormone in human and mouse hypothalamus.14
198935842010Identification of 15 loci influencing height in a Korean population.58
208887362010Analysis of the expression profile of CRH-POMC system genes in vitiligo skin biopsies.2
198935842010Identification of 15 loci influencing height in a Korean population.58

Citation

Dessen P

PMCH (pro-melanin concentrating hormone)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/72011/pmch-(pro-melanin-concentrating-hormone)