PNPLA7 (patatin like phospholipase domain containing 7)

2014-11-01 Affiliation

Identity

HGNC

PNPLA7

LOCATION

9q34.3

LOCUSID

375775

ALIAS

C9orf111,NTE-R1,NTEL1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 375775
MIM: 612122
HGNC: 24768
Ensembl: ENSG00000130653

Variants:

dbSNP: 375775
ClinVar: 375775
TCGA: ENSG00000130653
COSMIC: PNPLA7

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000130653	ENST00000277531	Q6ZV29
ENSG00000130653	ENST00000406427	Q6ZV29
ENSG00000130653	ENST00000491019	F2Z2D4

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Glycerophospholipid metabolism	KEGG	ko00564
Glycerophospholipid metabolism	KEGG	hsa00564
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Phospholipid metabolism	REACTOME	R-HSA-1483257
PI Metabolism	REACTOME	R-HSA-1483255
Glycerophospholipid catabolism	REACTOME	R-HSA-6814848

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
36979406	2023	The Lysophospholipase PNPLA7 Controls Hepatic Choline and Methionine Metabolism.	2
37861523	2023	The phospholipase PNPLA7 functions as a positive indicator in human colorectal and gastric cancers.	0
36979406	2023	The Lysophospholipase PNPLA7 Controls Hepatic Choline and Methionine Metabolism.	2
37861523	2023	The phospholipase PNPLA7 functions as a positive indicator in human colorectal and gastric cancers.	0
36499308	2022	The Patatin-Like Phospholipase Domain Containing Protein 7 Regulates Macrophage Classical Activation through SIRT1/NF-κB and p38 MAPK Pathways.	4
36499308	2022	The Patatin-Like Phospholipase Domain Containing Protein 7 Regulates Macrophage Classical Activation through SIRT1/NF-κB and p38 MAPK Pathways.	4
32103509	2020	The Patatin-Like Phospholipase Domain Containing Protein 7 Facilitates VLDL Secretion by Modulating ApoE Stability.	14
32103509	2020	The Patatin-Like Phospholipase Domain Containing Protein 7 Facilitates VLDL Secretion by Modulating ApoE Stability.	14
28887301	2017	The phospholipase PNPLA7 functions as a lysophosphatidylcholine hydrolase and interacts with lipid droplets through its catalytic domain.	15
28887301	2017	The phospholipase PNPLA7 functions as a lysophosphatidylcholine hydrolase and interacts with lipid droplets through its catalytic domain.	15
25867316	2015	Correlation analysis of the PNPLA7 gene polymorphism and susceptibility to menstrual disorder.	3
25867316	2015	Correlation analysis of the PNPLA7 gene polymorphism and susceptibility to menstrual disorder.	3

Citation

Dessen P

PNPLA7 (patatin like phospholipase domain containing 7)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/72033/pnpla7-(patatin-like-phospholipase-domain-containing-7)