POLR3C (RNA polymerase III subunit C)

2014-11-01  

Identity

HGNC
LOCATION
1q21.1
LOCUSID
ALIAS
C82,RPC3,RPC62
FUSION GENES

Other Information

Locus ID:

NCBI: 10623
MIM: 617454
HGNC: 30076
Ensembl: ENSG00000186141

Variants:

dbSNP: 10623
ClinVar: 10623
TCGA: ENSG00000186141
COSMIC: POLR3C

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000186141ENST00000334163Q9BUI4
ENSG00000186141ENST00000334163A0A024R4C1
ENSG00000186141ENST00000369294E9PHH9

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
Purine metabolismKEGGko00230
Pyrimidine metabolismKEGGko00240
RNA polymeraseKEGGko03020
Purine metabolismKEGGhsa00230
Pyrimidine metabolismKEGGhsa00240
RNA polymeraseKEGGhsa03020
Cytosolic DNA-sensing pathwayKEGGko04623
Cytosolic DNA-sensing pathwayKEGGhsa04623
Metabolic pathwaysKEGGhsa01100
RNA polymerase III, eukaryotesKEGGhsa_M00181
Epstein-Barr virus infectionKEGGhsa05169
Epstein-Barr virus infectionKEGGko05169
RNA polymerase III, eukaryotesKEGGM00181
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Cytosolic sensors of pathogen-associated DNAREACTOMER-HSA-1834949
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase I, RNA Polymerase III, and Mitochondrial TranscriptionREACTOMER-HSA-504046
RNA Polymerase III TranscriptionREACTOMER-HSA-74158
RNA Polymerase III Abortive And Retractive InitiationREACTOMER-HSA-749476
RNA Polymerase III Transcription InitiationREACTOMER-HSA-76046
RNA Polymerase III Transcription Initiation From Type 1 PromoterREACTOMER-HSA-76061
RNA Polymerase III Transcription Initiation From Type 2 PromoterREACTOMER-HSA-76066
RNA Polymerase III Transcription Initiation From Type 3 PromoterREACTOMER-HSA-76071
RNA Polymerase III Chain ElongationREACTOMER-HSA-73780
RNA Polymerase III Transcription TerminationREACTOMER-HSA-73980

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
326001522020From Rare Copy Number Variants to Biological Processes in ADHD.14
326001522020From Rare Copy Number Variants to Biological Processes in ADHD.14
315290522019The hRPC62 subunit of human RNA polymerase III displays helicase activity.3
315290522019The hRPC62 subunit of human RNA polymerase III displays helicase activity.3
287830422017Inborn errors in RNA polymerase III underlie severe varicella zoster virus infections.82
287830422017Inborn errors in RNA polymerase III underlie severe varicella zoster virus infections.82
209701192011Convergent animal and human evidence suggests a role of PPM1A gene in response to antidepressants.19
213586282011Structure-function analysis of hRPC62 provides insights into RNA polymerase III transcription initiation.25
209701192011Convergent animal and human evidence suggests a role of PPM1A gene in response to antidepressants.19
213586282011Structure-function analysis of hRPC62 provides insights into RNA polymerase III transcription initiation.25

Citation

Dessen P

POLR3C (RNA polymerase III subunit C)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/72056/polr3c-(rna-polymerase-iii-subunit-c)