POLR3K (RNA polymerase III subunit K)

2014-11-01  

Identity

HGNC
LOCATION
16p13.3
LOCUSID
ALIAS
C11,C11-RNP3,HLD21,My010,RPC10,RPC11,RPC12.5
FUSION GENES

Other Information

Locus ID:

NCBI: 51728
MIM: 606007
HGNC: 14121
Ensembl: ENSG00000161980

Variants:

dbSNP: 51728
ClinVar: 51728
TCGA: ENSG00000161980
COSMIC: POLR3K

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000161980ENST00000293860Q9Y2Y1

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Purine metabolismKEGGko00230
Pyrimidine metabolismKEGGko00240
RNA polymeraseKEGGko03020
Purine metabolismKEGGhsa00230
Pyrimidine metabolismKEGGhsa00240
RNA polymeraseKEGGhsa03020
Cytosolic DNA-sensing pathwayKEGGko04623
Cytosolic DNA-sensing pathwayKEGGhsa04623
Metabolic pathwaysKEGGhsa01100
RNA polymerase III, eukaryotesKEGGhsa_M00181
Epstein-Barr virus infectionKEGGhsa05169
Epstein-Barr virus infectionKEGGko05169
RNA polymerase III, eukaryotesKEGGM00181
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Cytosolic sensors of pathogen-associated DNAREACTOMER-HSA-1834949
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase I, RNA Polymerase III, and Mitochondrial TranscriptionREACTOMER-HSA-504046
RNA Polymerase III TranscriptionREACTOMER-HSA-74158
RNA Polymerase III Abortive And Retractive InitiationREACTOMER-HSA-749476
RNA Polymerase III Transcription InitiationREACTOMER-HSA-76046
RNA Polymerase III Transcription Initiation From Type 1 PromoterREACTOMER-HSA-76061
RNA Polymerase III Transcription Initiation From Type 2 PromoterREACTOMER-HSA-76066
RNA Polymerase III Transcription Initiation From Type 3 PromoterREACTOMER-HSA-76071
RNA Polymerase III Chain ElongationREACTOMER-HSA-73780
RNA Polymerase III Transcription TerminationREACTOMER-HSA-73980

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
335587642021Cryo-EM structures of human RNA polymerase III in its unbound and transcribing states.42
335587642021Cryo-EM structures of human RNA polymerase III in its unbound and transcribing states.42
262882492015Variability of Gene Expression Identifies Transcriptional Regulators of Early Human Embryonic Development.25
262882492015Variability of Gene Expression Identifies Transcriptional Regulators of Early Human Embryonic Development.25
174990432007Mammalian Maf1 is a negative regulator of transcription by all three nuclear RNA polymerases.79
174990432007Mammalian Maf1 is a negative regulator of transcription by all three nuclear RNA polymerases.79

Citation

Dessen P

POLR3K (RNA polymerase III subunit K)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/72062/new-content/meetings/