POMT2 (protein O-mannosyltransferase 2)

2014-11-01  

Identity

HGNC
LOCATION
14q24.3
LOCUSID
ALIAS
LGMD2N,LGMDR14,MDDGA2,MDDGB2,MDDGC2
FUSION GENES

Other Information

Locus ID:

NCBI: 29954
MIM: 607439
HGNC: 19743
Ensembl: ENSG00000009830

Variants:

dbSNP: 29954
ClinVar: 29954
TCGA: ENSG00000009830
COSMIC: POMT2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000009830ENST00000261534Q9UKY4
ENSG00000009830ENST00000554948G3V4X9
ENSG00000009830ENST00000555710H0YJK9
ENSG00000009830ENST00000556171H0YJJ4
ENSG00000009830ENST00000556326Q9UKY4
ENSG00000009830ENST00000556394H0YJQ7
ENSG00000009830ENST00000557289H0YJA9
ENSG00000009830ENST00000602717A0A0J9YVW4

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Other types of O-glycan biosynthesisKEGGko00514
Other types of O-glycan biosynthesisKEGGhsa00514
Metabolic pathwaysKEGGhsa01100
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
O-linked glycosylationREACTOMER-HSA-5173105
Mannose type O-glycan biosynthesisKEGGko00515
Mannose type O-glycan biosynthesisKEGGhsa00515

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
362176042023Clinical exome sequencing identifies novel compound heterozygous mutations of the POMT2 gene in patients with limb-girdle muscular dystrophy.0
362176042023Clinical exome sequencing identifies novel compound heterozygous mutations of the POMT2 gene in patients with limb-girdle muscular dystrophy.0
345657392021POMT1 and POMT2 gene mutations result in 2 cases of alpha-dystroglycanopathy.0
345657392021POMT1 and POMT2 gene mutations result in 2 cases of alpha-dystroglycanopathy.0
291758982018Limb girdle muscular dystrophy due to mutations in POMT2.11
291758982018Limb girdle muscular dystrophy due to mutations in POMT2.11
285121292017Mammalian O-mannosylation of cadherins and plexins is independent of protein O-mannosyltransferases 1 and 2.23
288158912017Cystic kidneys in fetal Walker-Warburg syndrome with POMT2 mutation: Intrafamilial phenotypic variability in four siblings and review of literature.2
289803842017Noncompaction cardiomyopathy in an infant with Walker-Warburg syndrome.2
285121292017Mammalian O-mannosylation of cadherins and plexins is independent of protein O-mannosyltransferases 1 and 2.23
288158912017Cystic kidneys in fetal Walker-Warburg syndrome with POMT2 mutation: Intrafamilial phenotypic variability in four siblings and review of literature.2
289803842017Noncompaction cardiomyopathy in an infant with Walker-Warburg syndrome.2
240021652014Novel cardiovascular findings in association with a POMT2 mutation: three siblings with α-dystroglycanopathy.5
240021652014Novel cardiovascular findings in association with a POMT2 mutation: three siblings with α-dystroglycanopathy.5
217827862011Different roles of the two components of human protein O-mannosyltransferase, POMT1 and POMT2.7

Citation

Dessen P

POMT2 (protein O-mannosyltransferase 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/72073/pomt2-(protein-o-mannosyltransferase-2)