PTS (6-pyruvoyltetrahydropterin synthase)

2014-11-01  

Identity

HGNC
LOCATION
11q23.1
LOCUSID
ALIAS
PTPS

Other Information

Locus ID:

NCBI: 5805
MIM: 612719
HGNC: 9689
Ensembl: ENSG00000150787

Variants:

dbSNP: 5805
ClinVar: 5805
TCGA: ENSG00000150787
COSMIC: PTS

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000150787ENST00000280362Q03393
ENSG00000150787ENST00000524931E9PNN3
ENSG00000150787ENST00000525803E9PJM0
ENSG00000150787ENST00000528679E9PKY8
ENSG00000150787ENST00000531673E9PKY8

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
Folate biosynthesisKEGGko00790
Folate biosynthesisKEGGhsa00790
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Metabolism of nitric oxideREACTOMER-HSA-202131
eNOS activation and regulationREACTOMER-HSA-203765
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulationREACTOMER-HSA-1474151

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
338228192021BH4-deficient hyperphenylalaninemia in Russia.11
339030162021Molecular and metabolic bases of tetrahydrobiopterin (BH(4)) deficiencies.19
338228192021BH4-deficient hyperphenylalaninemia in Russia.11
339030162021Molecular and metabolic bases of tetrahydrobiopterin (BH(4)) deficiencies.19
326511542020Long-term clinical outcome of 6-pyruvoyl-tetrahydropterin synthase-deficient patients.7
332344702020Retrospective analysis of 19 patients with 6-Pyruvoyl Tetrahydropterin Synthase Deficiency: Prolactin levels inversely correlate with growth.5
326511542020Long-term clinical outcome of 6-pyruvoyl-tetrahydropterin synthase-deficient patients.7
332344702020Retrospective analysis of 19 patients with 6-Pyruvoyl Tetrahydropterin Synthase Deficiency: Prolactin levels inversely correlate with growth.5
222375892012Mutation spectrum of and founder effects affecting the PTS gene in East Asian populations.17
222375892012Mutation spectrum of and founder effects affecting the PTS gene in East Asian populations.17
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.20
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.20
193505122009[Mutational analysis of patients with 6-pyruvoyltetrahydrobiopterin synthesis deficiency].2
194911462009Exhaustive analysis of BH4 and dopamine biosynthesis genes in patients with Dopa-responsive dystonia.43
196741212009Examination of tetrahydrobiopterin pathway genes in autism.7

Citation

Dessen P

PTS (6-pyruvoyltetrahydropterin synthase)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/72397/pts-(6-pyruvoyltetrahydropterin-synthase)