ATP2A3 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3)

2003-06-01   Dessen P  

Identity

HGNC
ATP2A3
LOCATION
17p13.2
LOCUSID
489
ALIAS
SERCA3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 489
MIM: 601929
HGNC: 813
Ensembl: ENSG00000074370

Variants:

dbSNP: 489
ClinVar: 489
TCGA: ENSG00000074370
COSMIC: ATP2A3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000074370ENST00000309890Q93084
ENSG00000074370ENST00000352011Q93084
ENSG00000074370ENST00000359983Q93084
ENSG00000074370ENST00000397035Q93084
ENSG00000074370ENST00000397041Q93084
ENSG00000074370ENST00000397043Q93084
ENSG00000074370ENST00000570845A0A0C4DGN3
ENSG00000074370ENST00000572116A0A0C4DGN1

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Calcium signaling pathwayKEGGko04020
Alzheimer's diseaseKEGGko05010
Calcium signaling pathwayKEGGhsa04020
Alzheimer's diseaseKEGGhsa05010
Pancreatic secretionKEGGko04972
Pancreatic secretionKEGGhsa04972
cGMP-PKG signaling pathwayKEGGhsa04022
cGMP-PKG signaling pathwayKEGGko04022
HemostasisREACTOMER-HSA-109582
Platelet homeostasisREACTOMER-HSA-418346
Platelet calcium homeostasisREACTOMER-HSA-418360
Reduction of cytosolic Ca++ levelsREACTOMER-HSA-418359
Signal TransductionREACTOMER-HSA-162582
Signaling by NOTCHREACTOMER-HSA-157118
Pre-NOTCH Expression and ProcessingREACTOMER-HSA-1912422
Pre-NOTCH Processing in GolgiREACTOMER-HSA-1912420
Muscle contractionREACTOMER-HSA-397014
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Ion channel transportREACTOMER-HSA-983712
Ion transport by P-type ATPasesREACTOMER-HSA-936837
Cardiac conductionREACTOMER-HSA-5576891
Ion homeostasisREACTOMER-HSA-5578775

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA448871celecoxibChemicalPathwayassociated22336956

References

Pubmed IDYearTitleCitations
381843842024Sarco/endoplasmic reticulum calcium ATPase 3 (SERCA3) expression in gastrointestinal stromal tumours.0
381843842024Sarco/endoplasmic reticulum calcium ATPase 3 (SERCA3) expression in gastrointestinal stromal tumours.0
306572102019Epigenetic regulation of the human ATP2A3 gene promoter in gastric and colon cancer cell lines.12
310232472019Salinomycin triggers endoplasmic reticulum stress through ATP2A3 upregulation in PC-3 cells.10
306572102019Epigenetic regulation of the human ATP2A3 gene promoter in gastric and colon cancer cell lines.12
310232472019Salinomycin triggers endoplasmic reticulum stress through ATP2A3 upregulation in PC-3 cells.10
274338312017Induction of cell differentiation activates transcription of the Sarco/Endoplasmic Reticulum calcium-ATPase 3 gene (ATP2A3) in gastric and colon cancer cells.11
276399652017Inhibition and conformational change of SERCA3b induced by Bcl-2.3
280114582017Insulin and Glucose Alter Death-Associated Protein Kinase 3 (DAPK3) DNA Methylation in Human Skeletal Muscle.17
274338312017Induction of cell differentiation activates transcription of the Sarco/Endoplasmic Reticulum calcium-ATPase 3 gene (ATP2A3) in gastric and colon cancer cells.11
276399652017Inhibition and conformational change of SERCA3b induced by Bcl-2.3
280114582017Insulin and Glucose Alter Death-Associated Protein Kinase 3 (DAPK3) DNA Methylation in Human Skeletal Muscle.17
242137202014Aberrant SERCA3 expression during the colorectal adenoma-adenocarcinoma sequence.6
242245132014Loss of endoplasmic reticulum calcium pump expression in choroid plexus tumours.0
252701192014Regulation of SERCA pumps expression in diabetes.0

Citation

Dessen P

ATP2A3 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/724/atp2a3-(atpase-sarcoplasmic-endoplasmic-reticulum-ca2+-transporting-3)