Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 54517
MIM: 616261
HGNC: 26033
Ensembl: ENSG00000091127
Variants:
dbSNP: 54517
ClinVar: 54517
TCGA: ENSG00000091127
COSMIC: PUS7
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000091127 | ENST00000356362 | Q96PZ0 |
| ENSG00000091127 | ENST00000469408 | Q96PZ0 |
| ENSG00000091127 | ENST00000481939 | E7EUH7 |
| ENSG00000091127 | ENST00000482157 | H0Y863 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Gene Expression | REACTOME | R-HSA-74160 |
| tRNA processing | REACTOME | R-HSA-72306 |
| tRNA modification in the nucleus and cytosol | REACTOME | R-HSA-6782315 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36222184 | 2023 | PUS7 promotes the proliferation of colorectal cancer cells by directly stabilizing SIRT1 to activate the Wnt/β-catenin pathway. | 6 |
| 36222184 | 2023 | PUS7 promotes the proliferation of colorectal cancer cells by directly stabilizing SIRT1 to activate the Wnt/β-catenin pathway. | 6 |
| 33811565 | 2022 | Pseudouridylate Synthase 7 Promotes Cell Proliferation and Invasion in Colon Cancer Through Activating PI3K/AKT/mTOR Signaling Pathway. | 8 |
| 35051350 | 2022 | Pseudouridine synthases modify human pre-mRNA co-transcriptionally and affect pre-mRNA processing. | 55 |
| 35144859 | 2022 | PUS7 deficiency in human patients causes profound neurodevelopmental phenotype by dysregulating protein translation. | 3 |
| 33811565 | 2022 | Pseudouridylate Synthase 7 Promotes Cell Proliferation and Invasion in Colon Cancer Through Activating PI3K/AKT/mTOR Signaling Pathway. | 8 |
| 35051350 | 2022 | Pseudouridine synthases modify human pre-mRNA co-transcriptionally and affect pre-mRNA processing. | 55 |
| 35144859 | 2022 | PUS7 deficiency in human patients causes profound neurodevelopmental phenotype by dysregulating protein translation. | 3 |
| 33990203 | 2021 | HSP90-dependent PUS7 overexpression facilitates the metastasis of colorectal cancer cells by regulating LASP1 abundance. | 22 |
| 34718722 | 2021 | The human pseudouridine synthase PUS7 recognizes RNA with an extended multi-domain binding surface. | 12 |
| 33990203 | 2021 | HSP90-dependent PUS7 overexpression facilitates the metastasis of colorectal cancer cells by regulating LASP1 abundance. | 22 |
| 34718722 | 2021 | The human pseudouridine synthase PUS7 recognizes RNA with an extended multi-domain binding surface. | 12 |
| 30778726 | 2019 | PUS7 mutations impair pseudouridylation in humans and cause intellectual disability and microcephaly. | 30 |
| 31451225 | 2019 | Biochemical insight into pseudouridine synthase 7 (PUS7) as a novel interactor of sirtuin, SIRT1. | 0 |
| 30778726 | 2019 | PUS7 mutations impair pseudouridylation in humans and cause intellectual disability and microcephaly. | 30 |
Citation
Dessen P
PUS7 (pseudouridine synthase 7)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/72402/pus7-(pseudouridine-synthase-7)
