Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5836
MIM: 613741
HGNC: 9725
Ensembl: ENSG00000100504
Variants:
dbSNP: 5836
ClinVar: 5836
TCGA: ENSG00000100504
COSMIC: PYGL
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000100504 | ENST00000216392 | P06737 |
| ENSG00000100504 | ENST00000532462 | E9PK47 |
| ENSG00000100504 | ENST00000544180 | P06737 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA446155 | Precursor Cell Lymphoblastic Leukemia-Lymphoma | Disease | ClinicalAnnotation | associated | PD | 23007406 | |
| PA448492 | asparaginase | Chemical | ClinicalAnnotation | associated | PD | 23007406 | |
| PA449247 | dexamethasone | Chemical | ClinicalAnnotation | associated | PD | 23007406 | |
| PA450428 | methotrexate | Chemical | ClinicalAnnotation | associated | PD | 23007406 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 35037470 | 2022 | Identification of PYGL as a key prognostic gene of glioma by integrated bioinformatics analysis. | 2 |
| 35611851 | 2022 | miR-155-5p regulates hypoxia-induced pulmonary artery smooth muscle cell function by targeting PYGL. | 6 |
| 35037470 | 2022 | Identification of PYGL as a key prognostic gene of glioma by integrated bioinformatics analysis. | 2 |
| 35611851 | 2022 | miR-155-5p regulates hypoxia-induced pulmonary artery smooth muscle cell function by targeting PYGL. | 6 |
| 33879691 | 2021 | Glycogen storage disease type VI with a novel PYGL mutation: Two case reports and literature review. | 5 |
| 34516362 | 2021 | Long noncoding RNA KCNMB2-AS1 promotes the development of esophageal cancer by modulating the miR-3194-3p/PYGL axis. | 8 |
| 34675331 | 2021 | Human hair follicles operate an internal Cori cycle and modulate their growth via glycogen phosphorylase. | 9 |
| 33879691 | 2021 | Glycogen storage disease type VI with a novel PYGL mutation: Two case reports and literature review. | 5 |
| 34516362 | 2021 | Long noncoding RNA KCNMB2-AS1 promotes the development of esophageal cancer by modulating the miR-3194-3p/PYGL axis. | 8 |
| 34675331 | 2021 | Human hair follicles operate an internal Cori cycle and modulate their growth via glycogen phosphorylase. | 9 |
| 32126244 | 2020 | The vitamin B6-regulated enzymes PYGL and G6PD fuel NADPH oxidases to promote skin inflammation. | 15 |
| 32268899 | 2020 | Novel PYGL mutations in Chinese children leading to glycogen storage disease type VI: two case reports. | 9 |
| 32892177 | 2020 | Glycogen storage disease type VI can progress to cirrhosis: ten Chinese patients with GSD VI and a literature review. | 6 |
| 32126244 | 2020 | The vitamin B6-regulated enzymes PYGL and G6PD fuel NADPH oxidases to promote skin inflammation. | 15 |
| 32268899 | 2020 | Novel PYGL mutations in Chinese children leading to glycogen storage disease type VI: two case reports. | 9 |
Citation
Dessen P
PYGL (glycogen phosphorylase L)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/72429/pygl-(glycogen-phosphorylase-l)
