PYROXD1 (pyridine nucleotide-disulphide oxidoreductase domain 1)

2014-11-01  

Identity

HGNC
LOCATION
12p12.1
LOCUSID
ALIAS
MFM8
FUSION GENES

Other Information

Locus ID:

NCBI: 79912
MIM: 617220
HGNC: 26162
Ensembl: ENSG00000121350

Variants:

dbSNP: 79912
ClinVar: 79912
TCGA: ENSG00000121350
COSMIC: PYROXD1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000121350ENST00000240651Q8WU10
ENSG00000121350ENST00000375266B5MDP1
ENSG00000121350ENST00000538582Q8WU10
ENSG00000121350ENST00000543476B4DEW4
ENSG00000121350ENST00000544187H0YGU0
ENSG00000121350ENST00000544970B4DEW4

Expression (GTEx)

0
5
10
15

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
369204812023Connective tissue presentation in two families expands the phenotypic spectrum of PYROXD1 disorders.0
369204812023Connective tissue presentation in two families expands the phenotypic spectrum of PYROXD1 disorders.0
336942782021Clinical and genetic characterization of PYROXD1-related myopathy patients from Turkey.2
339303332021The oxidoreductase PYROXD1 uses NAD(P)(+) as an antioxidant to sustain tRNA ligase activity in pre-tRNA splicing and unfolded protein response.12
336942782021Clinical and genetic characterization of PYROXD1-related myopathy patients from Turkey.2
339303332021The oxidoreductase PYROXD1 uses NAD(P)(+) as an antioxidant to sustain tRNA ligase activity in pre-tRNA splicing and unfolded protein response.12
320376072020Myopathy associated with homozygous PYROXD1 pathogenic variants detected by genome sequencing.3
320376072020Myopathy associated with homozygous PYROXD1 pathogenic variants detected by genome sequencing.3
305156272019Recessive PYROXD1 mutations cause adult-onset limb-girdle-type muscular dystrophy.7
315027052019A siRNA-based method for efficient silencing of PYROXD1 gene expression in the colon cancer cell line HCT116.3
305156272019Recessive PYROXD1 mutations cause adult-onset limb-girdle-type muscular dystrophy.7
315027052019A siRNA-based method for efficient silencing of PYROXD1 gene expression in the colon cancer cell line HCT116.3
303459042018Impact of PYROXD1 deficiency on cellular respiration and correlations with genetic analyses of limb-girdle muscular dystrophy in Saudi Arabia and Sudan.10
303459042018Impact of PYROXD1 deficiency on cellular respiration and correlations with genetic analyses of limb-girdle muscular dystrophy in Saudi Arabia and Sudan.10
277458332016Variants in the Oxidoreductase PYROXD1 Cause Early-Onset Myopathy with Internalized Nuclei and Myofibrillar Disorganization.26

Citation

Dessen P

PYROXD1 (pyridine nucleotide-disulphide oxidoreductase domain 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/72432/pyroxd1-(pyridine-nucleotide-disulphide-oxidoreductase-domain-1)