Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 29098
MIM: 607954
HGNC: 17679
Ensembl: ENSG00000108961
Variants:
dbSNP: 29098
ClinVar: 29098
TCGA: ENSG00000108961
COSMIC: RANGRF
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000108961 | ENST00000226105 | Q9HD47 |
| ENSG00000108961 | ENST00000407006 | Q9HD47 |
| ENSG00000108961 | ENST00000439238 | Q9HD47 |
| ENSG00000108961 | ENST00000580434 | Q9HD47 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Muscle contraction | REACTOME | R-HSA-397014 |
| Cardiac conduction | REACTOME | R-HSA-5576891 |
| Phase 0 - rapid depolarisation | REACTOME | R-HSA-5576892 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 30282806 | 2018 | Mechanistic insights into the interaction of the MOG1 protein with the cardiac sodium channel Na(v)1.5 clarify the molecular basis of Brugada syndrome. | 9 |
| 30282806 | 2018 | Mechanistic insights into the interaction of the MOG1 protein with the cardiac sodium channel Na(v)1.5 clarify the molecular basis of Brugada syndrome. | 9 |
| 24438356 | 2015 | The perfect storm? Histiocytoid cardiomyopathy and compound CACNA2D1 and RANGRF mutation in a baby. | 6 |
| 24438356 | 2015 | The perfect storm? Histiocytoid cardiomyopathy and compound CACNA2D1 and RANGRF mutation in a baby. | 6 |
| 24142675 | 2014 | Brugada syndrome and p.E61X_RANGRF. | 6 |
| 24142675 | 2014 | Brugada syndrome and p.E61X_RANGRF. | 6 |
| 21447824 | 2011 | MOG1: a new susceptibility gene for Brugada syndrome. | 63 |
| 21621375 | 2011 | A novel nonsense variant in Nav1.5 cofactor MOG1 eliminates its sodium current increasing effect and may increase the risk of arrhythmias. | 26 |
| 21447824 | 2011 | MOG1: a new susceptibility gene for Brugada syndrome. | 63 |
| 21621375 | 2011 | A novel nonsense variant in Nav1.5 cofactor MOG1 eliminates its sodium current increasing effect and may increase the risk of arrhythmias. | 26 |
| 18184654 | 2008 | Identification of a new co-factor, MOG1, required for the full function of cardiac sodium channel Nav 1.5. | 42 |
| 18184654 | 2008 | Identification of a new co-factor, MOG1, required for the full function of cardiac sodium channel Nav 1.5. | 42 |
Citation
Dessen P
RANGRF (RAN guanine nucleotide release factor)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/72485/rangrf-(ran-guanine-nucleotide-release-factor)
