ATP6V0A1 (ATPase H+ transporting V0 subunit a1)

2003-06-01 Affiliation

Identity

HGNC

ATP6V0A1

LOCATION

17q21.2

LOCUSID

535

ALIAS

ATP6N1,ATP6N1A,Stv1,VPP1,Vph1,a1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 535
MIM: 192130
HGNC: 865
Ensembl: ENSG00000033627

Variants:

dbSNP: 535
ClinVar: 535
TCGA: ENSG00000033627
COSMIC: ATP6V0A1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000033627	ENST00000264649	Q93050
ENSG00000033627	ENST00000343619	Q93050
ENSG00000033627	ENST00000393829	Q93050
ENSG00000033627	ENST00000537728	B7Z641
ENSG00000033627	ENST00000544137	F5H1T6
ENSG00000033627	ENST00000585525	B7Z2A9
ENSG00000033627	ENST00000586201	K7ERA6
ENSG00000033627	ENST00000587510	K7ERA0
ENSG00000033627	ENST00000587824	K7EM24
ENSG00000033627	ENST00000588138	K7ENA1
ENSG00000033627	ENST00000588901	K7EQW2
ENSG00000033627	ENST00000589213	K7ELZ6
ENSG00000033627	ENST00000589727	K7EPG4
ENSG00000033627	ENST00000592324	K7EN36

Expression (GTEx)

100

150

200

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Oxidative phosphorylation	KEGG	ko00190
Vibrio cholerae infection	KEGG	ko05110
Epithelial cell signaling in Helicobacter pylori infection	KEGG	ko05120
Oxidative phosphorylation	KEGG	hsa00190
Vibrio cholerae infection	KEGG	hsa05110
Epithelial cell signaling in Helicobacter pylori infection	KEGG	hsa05120
Lysosome	KEGG	ko04142
Lysosome	KEGG	hsa04142
Metabolic pathways	KEGG	hsa01100
Collecting duct acid secretion	KEGG	ko04966
Collecting duct acid secretion	KEGG	hsa04966
Phagosome	KEGG	ko04145
Phagosome	KEGG	hsa04145
Rheumatoid arthritis	KEGG	ko05323
Rheumatoid arthritis	KEGG	hsa05323
Tuberculosis	KEGG	ko05152
Tuberculosis	KEGG	hsa05152
Synaptic vesicle cycle	KEGG	ko04721
Synaptic vesicle cycle	KEGG	hsa04721
V-type ATPase, eukaryotes	KEGG	hsa_M00160
V-type ATPase, eukaryotes	KEGG	M00160
ROS, RNS production in phagocytes	REACTOME	R-HSA-1222556
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
Signal Transduction	REACTOME	R-HSA-162582
Signaling by Insulin receptor	REACTOME	R-HSA-74752
Insulin receptor recycling	REACTOME	R-HSA-77387
Transmembrane transport of small molecules	REACTOME	R-HSA-382551
Iron uptake and transport	REACTOME	R-HSA-917937
Transferrin endocytosis and recycling	REACTOME	R-HSA-917977
Ion channel transport	REACTOME	R-HSA-983712
Neutrophil degranulation	REACTOME	R-HSA-6798695

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
33833240	2021	ATP6V0A1 encoding the a1-subunit of the V0 domain of vacuolar H(+)-ATPases is essential for brain development in humans and mice.	0
34904569	2021	V-ATPase V0a1 promotes Weibel-Palade body biogenesis through the regulation of membrane fission.	5
33833240	2021	ATP6V0A1 encoding the a1-subunit of the V0 domain of vacuolar H(+)-ATPases is essential for brain development in humans and mice.	0
34904569	2021	V-ATPase V0a1 promotes Weibel-Palade body biogenesis through the regulation of membrane fission.	5
24072707	2013	The function of vacuolar ATPase (V-ATPase) a subunit isoforms in invasiveness of MCF10a and MCF10CA1a human breast cancer cells.	0
24072707	2013	The function of vacuolar ATPase (V-ATPase) a subunit isoforms in invasiveness of MCF10a and MCF10CA1a human breast cancer cells.	0
22708544	2012	Inhibition of lysosome degradation on autophagosome formation and responses to GMI, an immunomodulatory protein from Ganoderma microsporum.	21
22708544	2012	Inhibition of lysosome degradation on autophagosome formation and responses to GMI, an immunomodulatory protein from Ganoderma microsporum.	21
20038947	2011	Novel loci for major depression identified by genome-wide association study of Sequenced Treatment Alternatives to Relieve Depression and meta-analysis of three studies.	0
21558123	2011	A common genetic variant in the 3'-UTR of vacuolar H+-ATPase ATP6V0A1 creates a micro-RNA motif to alter chromogranin A processing and hypertension risk.	10
20038947	2011	Novel loci for major depression identified by genome-wide association study of Sequenced Treatment Alternatives to Relieve Depression and meta-analysis of three studies.	0
21558123	2011	A common genetic variant in the 3'-UTR of vacuolar H+-ATPase ATP6V0A1 creates a micro-RNA motif to alter chromogranin A processing and hypertension risk.	10
18505059	2008	POLR2F, ATP6V0A1 and PRNP expression in colorectal cancer: new molecules with prognostic significance?	30
18505059	2008	POLR2F, ATP6V0A1 and PRNP expression in colorectal cancer: new molecules with prognostic significance?	30

Citation

Dessen P

ATP6V0A1 (ATPase H+ transporting V0 subunit a1)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/725/atp6v0a1-(atpase-h+-transporting-v0-subunit-a1)