Identity
HGNC
LOCATION
5q22.2
LOCUSID
ALIAS
C5orf18,D5S346,DP1,POB16,TB2,YOP1,Yip2e
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 7905
MIM: 125265
HGNC: 30077
Ensembl: ENSG00000129625
Variants:
dbSNP: 7905
ClinVar: 7905
TCGA: ENSG00000129625
COSMIC: REEP5
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Signal Transduction | REACTOME | R-HSA-162582 |
| Signaling by GPCR | REACTOME | R-HSA-372790 |
| GPCR downstream signaling | REACTOME | R-HSA-388396 |
| Olfactory Signaling Pathway | REACTOME | R-HSA-381753 |
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA447321 | Depressive Disorder, Major | Disease | ClinicalAnnotation | associated | PD | 22795047 | |
| PA449015 | citalopram | Chemical | ClinicalAnnotation | associated | PD | 22795047 | |
| PA449673 | fluoxetine | Chemical | ClinicalAnnotation | associated | PD | 22795047 | |
| PA450801 | paroxetine | Chemical | ClinicalAnnotation | associated | PD | 22795047 | |
| PA451333 | sertraline | Chemical | ClinicalAnnotation | associated | PD | 22795047 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37768083 | 2023 | The REEP5/TRAM1 complex binds SARS-CoV-2 NSP3 and promotes virus replication. | 1 |
| 37768083 | 2023 | The REEP5/TRAM1 complex binds SARS-CoV-2 NSP3 and promotes virus replication. | 1 |
| 32075961 | 2020 | REEP5 depletion causes sarco-endoplasmic reticulum vacuolization and cardiac functional defects. | 11 |
| 32075961 | 2020 | REEP5 depletion causes sarco-endoplasmic reticulum vacuolization and cardiac functional defects. | 11 |
| 27966653 | 2016 | The accessory proteins REEP5 and REEP6 refine CXCR1-mediated cellular responses and lung cancer progression. | 14 |
| 27966653 | 2016 | The accessory proteins REEP5 and REEP6 refine CXCR1-mediated cellular responses and lung cancer progression. | 14 |
| 22795047 | 2012 | Association of APC and REEP5 gene polymorphisms with major depression disorder and treatment response to antidepressants in a Han Chinese population. | 11 |
| 22795047 | 2012 | Association of APC and REEP5 gene polymorphisms with major depression disorder and treatment response to antidepressants in a Han Chinese population. | 11 |
| 20628086 | 2010 | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. | 15 |
| 20628086 | 2010 | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. | 15 |
| 19913121 | 2009 | Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. | 105 |
| 19913121 | 2009 | Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. | 105 |
Citation
Dessen P
REEP5 (receptor accessory protein 5)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/72572/reep5-(receptor-accessory-protein-5)
