RGS9 (regulator of G protein signaling 9)

2014-11-01 Affiliation

Identity

HGNC

RGS9

LOCATION

17q24.1

LOCUSID

8787

ALIAS

PERRS,RGS9L

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 8787
MIM: 604067
HGNC: 10004
Ensembl: ENSG00000108370

Variants:

dbSNP: 8787
ClinVar: 8787
TCGA: ENSG00000108370
COSMIC: RGS9

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000108370	ENST00000262406	O75916
ENSG00000108370	ENST00000443584	E9PD91
ENSG00000108370	ENST00000449996	O75916
ENSG00000108370	ENST00000584234	J3QL70
ENSG00000108370	ENST00000635833	A0A1B0GVU3

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Phototransduction	KEGG	ko04744
Phototransduction	KEGG	hsa04744
Cocaine addiction	KEGG	hsa05030
Cocaine addiction	KEGG	ko05030
Metabolism of proteins	REACTOME	R-HSA-392499
Protein folding	REACTOME	R-HSA-391251
Chaperonin-mediated protein folding	REACTOME	R-HSA-390466
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (i) signalling events	REACTOME	R-HSA-418594
Visual phototransduction	REACTOME	R-HSA-2187338
The phototransduction cascade	REACTOME	R-HSA-2514856
Inactivation, recovery and regulation of the phototransduction cascade	REACTOME	R-HSA-2514859
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	REACTOME	R-HSA-6814122

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
29107794	2017	The clinical presentation of bradyopsia in children.	2
29107794	2017	The clinical presentation of bradyopsia in children.	2
25591550	2015	Evidence for the contribution of genetic variations in regulator of G protein signaling 9 to the genetic susceptibility of heroin dependence.	1
26345773	2015	Regulators of G-protein signaling 9 genetic variations in Chinese subjects with schizophrenia.	0
25591550	2015	Evidence for the contribution of genetic variations in regulator of G protein signaling 9 to the genetic susceptibility of heroin dependence.	1
26345773	2015	Regulators of G-protein signaling 9 genetic variations in Chinese subjects with schizophrenia.	0
23857581	2013	Macromolecular composition dictates receptor and G protein selectivity of regulator of G protein signaling (RGS) 7 and 9-2 protein complexes in living cells.	40
23857581	2013	Macromolecular composition dictates receptor and G protein selectivity of regulator of G protein signaling (RGS) 7 and 9-2 protein complexes in living cells.	40
21511947	2011	Type 5 G protein beta subunit (Gbeta5) controls the interaction of regulator of G protein signaling 9 (RGS9) with membrane anchors.	18
22006018	2011	β-arrestin2 plays permissive roles in the inhibitory activities of RGS9-2 on G protein-coupled receptors by maintaining RGS9-2 in the open conformation.	12
22132185	2011	Association between regulator of G protein signaling 9-2 and body weight.	5
21511947	2011	Type 5 G protein beta subunit (Gbeta5) controls the interaction of regulator of G protein signaling 9 (RGS9) with membrane anchors.	18
22006018	2011	β-arrestin2 plays permissive roles in the inhibitory activities of RGS9-2 on G protein-coupled receptors by maintaining RGS9-2 in the open conformation.	12
22132185	2011	Association between regulator of G protein signaling 9-2 and body weight.	5
19818506	2010	Novel mutations and electrophysiologic findings in RGS9- and R9AP-associated retinal dysfunction (Bradyopsia).	18

Citation

Dessen P

RGS9 (regulator of G protein signaling 9)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/72620/rgs9-(regulator-of-g-protein-signaling-9)