ATRX (ATRX chromatin remodeler)

2003-08-01  

Identity

HGNC
LOCATION
Xq21.1
LOCUSID
ALIAS
JMS,MRX52,RAD54,RAD54L,XH2,XNP,ZNF-HX
FUSION GENES

Other Information

Locus ID:

NCBI: 546
MIM: 300032
HGNC: 886
Ensembl: ENSG00000085224

Variants:

dbSNP: 546
ClinVar: 546
TCGA: ENSG00000085224
COSMIC: ATRX

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000085224ENST00000373344P46100
ENSG00000085224ENST00000373344A4LAA3
ENSG00000085224ENST00000395603P46100
ENSG00000085224ENST00000400866H0Y3T0
ENSG00000085224ENST00000480283A0A087WWG0
ENSG00000085224ENST00000493470A0A096LP59
ENSG00000085224ENST00000622960A0A096LPG6
ENSG00000085224ENST00000623242A0A096LNR8
ENSG00000085224ENST00000623316A0A096LNX6
ENSG00000085224ENST00000623321A0A096LNN3
ENSG00000085224ENST00000624032A0A096LNW1
ENSG00000085224ENST00000624166A0A096LNL9
ENSG00000085224ENST00000624668A0A096LNL7
ENSG00000085224ENST00000625063A0A096LNL6

Expression (GTEx)

0
5
10
15
20
25

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
379040292024Integrated omics analyses clarifies ATRX copy number variant of uncertain significance.0
380382522024DAXX promotes centromeric stability independently of ATRX by preventing the accumulation of R-loop-induced DNA double-stranded breaks.0
381019982024Multiparametric MRI and T2/FLAIR mismatch complements the World Health Organization 2021 classification for the diagnosis of IDH-mutant 1p/19q non-co-deleted/ATRX-mutant astrocytoma.1
384773522024ATRX guards against aberrant differentiation in mesenchymal progenitor cells.0
386094332024Combined deletion of MEN1, ATRX and PTEN triggers development of high-grade pancreatic neuroendocrine tumors in mice.0
379040292024Integrated omics analyses clarifies ATRX copy number variant of uncertain significance.0
380382522024DAXX promotes centromeric stability independently of ATRX by preventing the accumulation of R-loop-induced DNA double-stranded breaks.0
381019982024Multiparametric MRI and T2/FLAIR mismatch complements the World Health Organization 2021 classification for the diagnosis of IDH-mutant 1p/19q non-co-deleted/ATRX-mutant astrocytoma.1
384773522024ATRX guards against aberrant differentiation in mesenchymal progenitor cells.0
386094332024Combined deletion of MEN1, ATRX and PTEN triggers development of high-grade pancreatic neuroendocrine tumors in mice.0
356912892023DAXX, ATRX, and MSI in PanNET and Their Metastases: Correlation with Histopathological Data and Prognosis.0
365415512023Alternative lengthening of telomeres (ALT) in pediatric high-grade gliomas can occur without ATRX mutation and is enriched in patients with pathogenic germline mismatch repair (MMR) variants.0
368943742023ATRX, a guardian of chromatin.12
369330122023Glioneuronal tumor with ATRX alteration, kinase fusion and anaplastic features (GTAKA): a molecularly distinct brain tumor type with recurrent NTRK gene fusions.0
371716062023A new mouse model of ATR-X syndrome carrying a common patient mutation exhibits neurological and morphological defects.1

Citation

Dessen P

ATRX (ATRX chromatin remodeler)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/729/atrx-(atrx-chromatin-remodeler)