Identity
HGNC
LOCATION
22q12.3
LOCUSID
ALIAS
C22orf28,DJ149A16.6,FAAP,HSPC117
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 51493
MIM: 613901
HGNC: 26935
Ensembl: ENSG00000100220
Variants:
dbSNP: 51493
ClinVar: 51493
TCGA: ENSG00000100220
COSMIC: RTCB
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000100220 | ENST00000216038 | Q9Y3I0 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Gene Expression | REACTOME | R-HSA-74160 |
| tRNA processing | REACTOME | R-HSA-72306 |
| tRNA processing in the nucleus | REACTOME | R-HSA-6784531 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38493148 | 2024 | Structural and mechanistic insights into activation of the human RNA ligase RTCB by Archease. | 0 |
| 38493148 | 2024 | Structural and mechanistic insights into activation of the human RNA ligase RTCB by Archease. | 0 |
| 37556111 | 2023 | The RNA-Splicing Ligase RTCB Promotes Influenza A Virus Replication by Suppressing Innate Immunity via Interaction with RNA Helicase DDX1. | 0 |
| 37556111 | 2023 | The RNA-Splicing Ligase RTCB Promotes Influenza A Virus Replication by Suppressing Innate Immunity via Interaction with RNA Helicase DDX1. | 0 |
| 34854379 | 2021 | Molecular architecture of the human tRNA ligase complex. | 15 |
| 34854379 | 2021 | Molecular architecture of the human tRNA ligase complex. | 15 |
| 28707320 | 2017 | Homology model of the human tRNA splicing ligase RtcB. | 10 |
| 28707320 | 2017 | Homology model of the human tRNA splicing ligase RtcB. | 10 |
| 24608264 | 2014 | hCLE/C14orf166 associates with DDX1-HSPC117-FAM98B in a novel transcription-dependent shuttling RNA-transporting complex. | 33 |
| 24941254 | 2014 | HSPC117 is regulated by epigenetic modification and is involved in the migration of JEG-3 cells. | 2 |
| 25378478 | 2014 | The mammalian tRNA ligase complex mediates splicing of XBP1 mRNA and controls antibody secretion in plasma cells. | 102 |
| 24608264 | 2014 | hCLE/C14orf166 associates with DDX1-HSPC117-FAM98B in a novel transcription-dependent shuttling RNA-transporting complex. | 33 |
| 24941254 | 2014 | HSPC117 is regulated by epigenetic modification and is involved in the migration of JEG-3 cells. | 2 |
| 25378478 | 2014 | The mammalian tRNA ligase complex mediates splicing of XBP1 mRNA and controls antibody secretion in plasma cells. | 102 |
| 21311021 | 2011 | HSPC117 is the essential subunit of a human tRNA splicing ligase complex. | 146 |
Citation
Dessen P
RTCB (RNA 2,3-cyclic phosphate and 5-OH ligase)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/72922/cancer-prone-explorer/new-content/
