Identity
HGNC
LOCATION
17q11.2
LOCUSID
ALIAS
HsTIR,MyD88-5,SAMD2,SARM,hSARM1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 23098
MIM: 607732
HGNC: 17074
Ensembl: ENSG00000004139
Variants:
dbSNP: 23098
ClinVar: 23098
TCGA: ENSG00000004139
COSMIC: SARM1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000004139 | ENST00000578128 | J3KSG7 |
| ENSG00000004139 | ENST00000579593 | J3KRZ6 |
| ENSG00000004139 | ENST00000582323 | J3QRE0 |
| ENSG00000004139 | ENST00000585482 | Q6SZW1 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38635746 | 2024 | The SARM1 TIR domain produces glycocyclic ADPR molecules as minor products. | 0 |
| 38692735 | 2024 | Context-Specific Stress Causes Compartmentalized SARM1 Activation and Local Degeneration in Cortical Neurons. | 0 |
| 38635746 | 2024 | The SARM1 TIR domain produces glycocyclic ADPR molecules as minor products. | 0 |
| 38692735 | 2024 | Context-Specific Stress Causes Compartmentalized SARM1 Activation and Local Degeneration in Cortical Neurons. | 0 |
| 34710262 | 2023 | The curious case of SARM1: Dr. Jekyll and Mr. Hyde in cell death and immunity? | 4 |
| 37083456 | 2023 | TIR-1/SARM1 inhibits axon regeneration and promotes axon degeneration. | 5 |
| 37742918 | 2023 | A phase transition reduces the threshold for nicotinamide mononucleotide-based activation of SARM1, an NAD(P) hydrolase, to physiologically relevant levels. | 0 |
| 34710262 | 2023 | The curious case of SARM1: Dr. Jekyll and Mr. Hyde in cell death and immunity? | 4 |
| 37083456 | 2023 | TIR-1/SARM1 inhibits axon regeneration and promotes axon degeneration. | 5 |
| 37742918 | 2023 | A phase transition reduces the threshold for nicotinamide mononucleotide-based activation of SARM1, an NAD(P) hydrolase, to physiologically relevant levels. | 0 |
| 34935867 | 2022 | Sarm1 activation produces cADPR to increase intra-axonal Ca++ and promote axon degeneration in PIPN. | 30 |
| 34991663 | 2022 | Constitutively active SARM1 variants that induce neuropathy are enriched in ALS patients. | 34 |
| 34993722 | 2022 | Circ_0044516 Enriches the Level of SARM1 as a miR-330-5p Sponge to Regulate Cell Malignant Behaviors and Tumorigenesis of Prostate Cancer. | 0 |
| 35224705 | 2022 | SARM1 can be a potential therapeutic target for spinal cord injury. | 2 |
| 35468924 | 2022 | TLR4 and SARM1 modulate survival and chemoresistance in an HPV-positive cervical cancer cell line. | 3 |
Citation
Dessen P
SARM1 (sterile alpha and TIR motif containing 1)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/72981/sarm1-(sterile-alpha-and-tir-motif-containing-1)
