Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 6336
MIM: 604427
HGNC: 10582
Ensembl: ENSG00000185313
Variants:
dbSNP: 6336
ClinVar: 6336
TCGA: ENSG00000185313
COSMIC: SCN10A
RNA/Proteins
Expression (GTEx)
Pathways
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA150481189 | taxanes | Chemical | ClinicalAnnotation | associated | PD | 26194361 | |
| PA159018367 | Brugada syndrome | Disease | MultilinkAnnotation | not associated | 25691538 | ||
| PA445204 | Ovarian Neoplasms | Disease | ClinicalAnnotation | associated | PD | 26194361 | |
| PA448803 | carboplatin | Chemical | ClinicalAnnotation | associated | PD | 26194361 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38263802 | 2024 | Heterologous expression of the human wild-type and variant Na(V) 1.8 (A1073V) in rat sensory neurons. | 0 |
| 38263802 | 2024 | Heterologous expression of the human wild-type and variant Na(V) 1.8 (A1073V) in rat sensory neurons. | 0 |
| 37122207 | 2023 | Patient-specific induced pluripotent stem cell properties implicate Ca(2+)-homeostasis in clinical arrhythmia associated with combined heterozygous RYR2 and SCN10A variants. | 4 |
| 37373335 | 2023 | Molecular and Functional Relevance of Na(V)1.8-Induced Atrial Arrhythmogenic Triggers in a Human SCN10A Knock-Out Stem Cell Model. | 3 |
| 37122207 | 2023 | Patient-specific induced pluripotent stem cell properties implicate Ca(2+)-homeostasis in clinical arrhythmia associated with combined heterozygous RYR2 and SCN10A variants. | 4 |
| 37373335 | 2023 | Molecular and Functional Relevance of Na(V)1.8-Induced Atrial Arrhythmogenic Triggers in a Human SCN10A Knock-Out Stem Cell Model. | 3 |
| 35103494 | 2022 | Clinical Implications of SCN10A Loss-of-Function Variants in 169 610 Exomes Representing the General Population. | 0 |
| 36140801 | 2022 | Biallelic Loss of Function Mutation in Sodium Channel Gene SCN10A in an Autism Spectrum Disorder Trio from Pakistan. | 0 |
| 35103494 | 2022 | Clinical Implications of SCN10A Loss-of-Function Variants in 169 610 Exomes Representing the General Population. | 0 |
| 36140801 | 2022 | Biallelic Loss of Function Mutation in Sodium Channel Gene SCN10A in an Autism Spectrum Disorder Trio from Pakistan. | 0 |
| 34312669 | 2021 | Common variants in SCN10A gene associated with Brugada syndrome. | 3 |
| 34645823 | 2021 | Disordered breathing in a Pitt-Hopkins syndrome model involves Phox2b-expressing parafacial neurons and aberrant Nav1.8 expression. | 11 |
| 34782600 | 2021 | Detrimental proarrhythmogenic interaction of Ca(2+)/calmodulin-dependent protein kinase II and Na(V)1.8 in heart failure. | 12 |
| 34930944 | 2021 | Contributions of Na(V)1.8 and Na(V)1.9 to excitability in human induced pluripotent stem-cell derived somatosensory neurons. | 4 |
| 34312669 | 2021 | Common variants in SCN10A gene associated with Brugada syndrome. | 3 |
Citation
Dessen P
SCN10A (sodium voltage-gated channel alpha subunit 10)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/73043/scn10a-(sodium-voltage-gated-channel-alpha-subunit-10)
