SCP2 (sterol carrier protein 2)

2014-11-01 Affiliation

Identity

HGNC

SCP2

LOCATION

1p32.3

LOCUSID

6342

ALIAS

NLTP,NSL-TP,SCOX,SCP-2,SCP-CHI,SCP-X,SCPX

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 6342
MIM: 184755
HGNC: 10606
Ensembl: ENSG00000116171

Variants:

dbSNP: 6342
ClinVar: 6342
TCGA: ENSG00000116171
COSMIC: SCP2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000116171	ENST00000371509	P22307
ENSG00000116171	ENST00000371513	P22307
ENSG00000116171	ENST00000371514	P22307
ENSG00000116171	ENST00000371514	A0A384NY87
ENSG00000116171	ENST00000407246	P22307
ENSG00000116171	ENST00000408941	P22307
ENSG00000116171	ENST00000430330	P22307
ENSG00000116171	ENST00000435345	P22307
ENSG00000116171	ENST00000478274	H0YF61
ENSG00000116171	ENST00000478631	E9PLD1
ENSG00000116171	ENST00000484100	H0YD06
ENSG00000116171	ENST00000488965	P22307
ENSG00000116171	ENST00000528311	P22307
ENSG00000116171	ENST00000529363	H0YCB0
ENSG00000116171	ENST00000533119	H0YEU8

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Primary bile acid biosynthesis	KEGG	ko00120
PPAR signaling pathway	KEGG	ko03320
Primary bile acid biosynthesis	KEGG	hsa00120
PPAR signaling pathway	KEGG	hsa03320
Peroxisome	KEGG	ko04146
Peroxisome	KEGG	hsa04146
Metabolic pathways	KEGG	hsa01100
Bile acid biosynthesis, cholesterol => cholate/chenodeoxycholate	KEGG	hsa_M00104
Bile acid biosynthesis, cholesterol => cholate/chenodeoxycholate	KEGG	M00104
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Peroxisomal lipid metabolism	REACTOME	R-HSA-390918
Beta-oxidation of pristanoyl-CoA	REACTOME	R-HSA-389887
Bile acid and bile salt metabolism	REACTOME	R-HSA-194068
Synthesis of bile acids and bile salts	REACTOME	R-HSA-192105
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	REACTOME	R-HSA-193368
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	REACTOME	R-HSA-2046104
alpha-linolenic acid (ALA) metabolism	REACTOME	R-HSA-2046106

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
34541823	2021	LINC00261 elevation inhibits angiogenesis and cell cycle progression of pancreatic cancer cells by upregulating SCP2 via targeting FOXP3.	3
34541823	2021	LINC00261 elevation inhibits angiogenesis and cell cycle progression of pancreatic cancer cells by upregulating SCP2 via targeting FOXP3.	3
31407919	2019	Methylation dependent microRNA 1285-5p and sterol carrier proteins 2 in type 2 diabetes mellitus.	7
31407919	2019	Methylation dependent microRNA 1285-5p and sterol carrier proteins 2 in type 2 diabetes mellitus.	7
28284963	2017	A structural appraisal of sterol carrier protein 2.	9
28284963	2017	A structural appraisal of sterol carrier protein 2.	9
27097688	2016	Perturbed rhythmic activation of signaling pathways in mice deficient for Sterol Carrier Protein 2-dependent diurnal lipid transport and metabolism.	7
27311714	2016	Super-resolution Microscopy Reveals Compartmentalization of Peroxisomal Membrane Proteins.	30
27097688	2016	Perturbed rhythmic activation of signaling pathways in mice deficient for Sterol Carrier Protein 2-dependent diurnal lipid transport and metabolism.	7
27311714	2016	Super-resolution Microscopy Reveals Compartmentalization of Peroxisomal Membrane Proteins.	30
24510313	2014	Sterol carrier protein-2: binding protein for endocannabinoids.	21
24510313	2014	Sterol carrier protein-2: binding protein for endocannabinoids.	21
21375735	2011	The Peroxisomal Targeting Signal 1 in sterol carrier protein 2 is autonomous and essential for receptor recognition.	4
21375735	2011	The Peroxisomal Targeting Signal 1 in sterol carrier protein 2 is autonomous and essential for receptor recognition.	4
20628086	2010	Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.	15

Citation

Dessen P

SCP2 (sterol carrier protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/73054/scp2-(sterol-carrier-protein-2)