SEC24C (SEC24 homolog C, COPII coat complex component)

2014-11-01  

Identity

HGNC
SEC24C
LOCATION
10q22.2
LOCUSID
9632
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9632
MIM: 607185
HGNC: 10705
Ensembl: ENSG00000176986

Variants:

dbSNP: 9632
ClinVar: 9632
TCGA: ENSG00000176986
COSMIC: SEC24C

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000176986ENST00000339365P53992
ENSG00000176986ENST00000339365A0A024QZM6
ENSG00000176986ENST00000345254P53992
ENSG00000176986ENST00000345254A0A024QZM6
ENSG00000176986ENST00000465076G5EA31
ENSG00000176986ENST00000634508A0A0U1RR49
ENSG00000176986ENST00000635550A0A0U1RR58

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
COPII complexKEGGhsa_M00404
COPII complexKEGGM00404
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Transport to the Golgi and subsequent modificationREACTOMER-HSA-948021
ER to Golgi Anterograde TransportREACTOMER-HSA-199977
COPII (Coat Protein 2) Mediated Vesicle TransportREACTOMER-HSA-204005
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen Presentation: Folding, assembly and peptide loading of class I MHCREACTOMER-HSA-983170
MHC class II antigen presentationREACTOMER-HSA-2132295
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Regulation of cholesterol biosynthesis by SREBP (SREBF)REACTOMER-HSA-1655829
Cargo concentration in the ERREACTOMER-HSA-5694530

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
183296162008Ebola virus matrix protein VP40 uses the COPII transport system for its intracellular transport.41
214546702011The serotonin transporter is an exclusive client of the coat protein complex II (COPII) component SEC24C.41
224046512012A triple arg motif mediates α(2B)-adrenergic receptor interaction with Sec24C/D and export.27
232888442013Switching the clientele: a lysine residing in the C terminus of the serotonin transporter specifies its preference for the coat protein complex II component SEC24C.27
150137492004Regulation of a COPII component by cytosolic O-glycosylation during mitosis.21
173737002007Association studies of 23 positional/functional candidate genes on chromosome 10 in late-onset Alzheimer's disease.15
236580222013A new class of endoplasmic reticulum export signal PhiXPhiXPhi for transmembrane proteins and its selective interaction with Sec24C.8
299391622018The COPII cargo adapter SEC24C is essential for neuronal homeostasis.6
282984392017Selective export of autotaxin from the endoplasmic reticulum.4
286797542017Sec24C-Dependent Transport of Claudin-1 Regulates Hepatitis C Virus Entry.4

Citation

Dessen P

SEC24C (SEC24 homolog C, COPII coat complex component)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/73094/sec24c-(sec24-homolog-c-copii-coat-complex-component)