SECISBP2 (SECIS binding protein 2)

2014-11-01  

Identity

HGNC
LOCATION
9q22.2
LOCUSID
ALIAS
SBP2
FUSION GENES

Other Information

Locus ID:

NCBI: 79048
MIM: 607693
HGNC: 30972
Ensembl: ENSG00000187742

Variants:

dbSNP: 79048
ClinVar: 79048
TCGA: ENSG00000187742
COSMIC: SECISBP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000187742ENST00000339901Q96T21
ENSG00000187742ENST00000375807Q96T21
ENSG00000187742ENST00000425851Q5HYY5
ENSG00000187742ENST00000440898Q4V370
ENSG00000187742ENST00000534113Q96T21

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Selenoamino acid metabolismREACTOMER-HSA-2408522
Selenocysteine synthesisREACTOMER-HSA-2408557

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
330778082021SECISBP2 is a novel prognostic predictor that regulates selenoproteins in diffuse large B-cell lymphoma.6
348847332021Human Genetic Disorders Resulting in Systemic Selenoprotein Deficiency.14
330778082021SECISBP2 is a novel prognostic predictor that regulates selenoproteins in diffuse large B-cell lymphoma.6
348847332021Human Genetic Disorders Resulting in Systemic Selenoprotein Deficiency.14
316820092020Whole transcriptome analysis of smoker palatal mucosa identifies multiple downregulated innate immunity genes.2
316820092020Whole transcriptome analysis of smoker palatal mucosa identifies multiple downregulated innate immunity genes.2
302477972018Selenium-sensitive miRNA-181a-5p targeting SBP2 regulates selenoproteins expression in cartilage.9
302867472018The hsa-miR-181a-5p reduces oxidation resistance by controlling SECISBP2 in osteoarthritis.21
302477972018Selenium-sensitive miRNA-181a-5p targeting SBP2 regulates selenoproteins expression in cartilage.9
302867472018The hsa-miR-181a-5p reduces oxidation resistance by controlling SECISBP2 in osteoarthritis.21
281156382017SECIS-binding protein 2 interacts with the SMN complex and the methylosome for selenoprotein mRNP assembly and translation.8
286239772017Loss of selenocysteine insertion sequence binding protein 2 suppresses the proliferation, migration/invasion and hormone secretion of human trophoblast cells via the PI3K/Akt and ERK signaling pathway.9
281156382017SECIS-binding protein 2 interacts with the SMN complex and the methylosome for selenoprotein mRNP assembly and translation.8
286239772017Loss of selenocysteine insertion sequence binding protein 2 suppresses the proliferation, migration/invasion and hormone secretion of human trophoblast cells via the PI3K/Akt and ERK signaling pathway.9
248508842014The SBP2 protein central to selenoprotein synthesis contacts the human ribosome at expansion segment 7L of the 28S rRNA.12

Citation

Dessen P

SECISBP2 (SECIS binding protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/73098/gene-fusions/cancer-prone-explorer/