Identity
HGNC
LOCATION
15q23
LOCUSID
ALIAS
DEN1,NEDP1,PRSC2
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 123228
MIM: 608659
HGNC: 22992
Ensembl: ENSG00000166192
Variants:
dbSNP: 123228
ClinVar: 123228
TCGA: ENSG00000166192
COSMIC: SENP8
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 31577950 | 2019 | The Balance between Mono- and NEDD8-Chains Controlled by NEDP1 upon DNA Damage Is a Regulatory Module of the HSP70 ATPase Activity. | 24 |
| 31577950 | 2019 | The Balance between Mono- and NEDD8-Chains Controlled by NEDP1 upon DNA Damage Is a Regulatory Module of the HSP70 ATPase Activity. | 24 |
| 28831681 | 2018 | NEDDylation antagonizes ubiquitination of proliferating cell nuclear antigen and regulates the recruitment of polymerase η in response to oxidative DNA damage. | 16 |
| 28831681 | 2018 | NEDDylation antagonizes ubiquitination of proliferating cell nuclear antigen and regulates the recruitment of polymerase η in response to oxidative DNA damage. | 16 |
| 28475037 | 2017 | SENP8 limits aberrant neddylation of NEDD8 pathway components to promote cullin-RING ubiquitin ligase function. | 21 |
| 28475037 | 2017 | SENP8 limits aberrant neddylation of NEDD8 pathway components to promote cullin-RING ubiquitin ligase function. | 21 |
| 25655932 | 2015 | NEDDylation promotes endothelial dysfunction: a role for HDAC2. | 18 |
| 26403403 | 2015 | PAPILLARY THYROID CANCER IS CHARACTERIZED BY ALTERED EXPRESSION OF GENES INVOLVED IN THE SUMOYLATION PROCESS. | 11 |
| 25655932 | 2015 | NEDDylation promotes endothelial dysfunction: a role for HDAC2. | 18 |
| 26403403 | 2015 | PAPILLARY THYROID CANCER IS CHARACTERIZED BY ALTERED EXPRESSION OF GENES INVOLVED IN THE SUMOYLATION PROCESS. | 11 |
| 23001041 | 2013 | NEDDylation controls the target specificity of E2F1 and apoptosis induction. | 25 |
| 23209320 | 2013 | Central role for endothelial human deneddylase-1/SENP8 in fine-tuning the vascular inflammatory response. | 31 |
| 23408908 | 2013 | Control of multicellular development by the physically interacting deneddylases DEN1/DenA and COP9 signalosome. | 25 |
| 23001041 | 2013 | NEDDylation controls the target specificity of E2F1 and apoptosis induction. | 25 |
| 23209320 | 2013 | Central role for endothelial human deneddylase-1/SENP8 in fine-tuning the vascular inflammatory response. | 31 |
Citation
Dessen P
SENP8 (SUMO peptidase family member, NEDD8 specific)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/73118/senp8-(sumo-peptidase-family-member-nedd8-specific)
