SENP8 (SUMO peptidase family member, NEDD8 specific)

2014-11-01  

Identity

HGNC
SENP8
LOCATION
15q23
LOCUSID
123228
ALIAS
DEN1,NEDP1,PRSC2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 123228
MIM: 608659
HGNC: 22992
Ensembl: ENSG00000166192

Variants:

dbSNP: 123228
ClinVar: 123228
TCGA: ENSG00000166192
COSMIC: SENP8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166192ENST00000340912Q96LD8
ENSG00000166192ENST00000542035Q96LD8
ENSG00000166192ENST00000564082H3BTK5
ENSG00000166192ENST00000564863H3BS71
ENSG00000166192ENST00000567794H3BTJ8

Expression (GTEx)

0
1
2
3
4
5
6
7
8
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
DeubiquitinationREACTOMER-HSA-5688426
UCH proteinasesREACTOMER-HSA-5689603

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
315779502019The Balance between Mono- and NEDD8-Chains Controlled by NEDP1 upon DNA Damage Is a Regulatory Module of the HSP70 ATPase Activity.24
315779502019The Balance between Mono- and NEDD8-Chains Controlled by NEDP1 upon DNA Damage Is a Regulatory Module of the HSP70 ATPase Activity.24
288316812018NEDDylation antagonizes ubiquitination of proliferating cell nuclear antigen and regulates the recruitment of polymerase η in response to oxidative DNA damage.16
288316812018NEDDylation antagonizes ubiquitination of proliferating cell nuclear antigen and regulates the recruitment of polymerase η in response to oxidative DNA damage.16
284750372017SENP8 limits aberrant neddylation of NEDD8 pathway components to promote cullin-RING ubiquitin ligase function.21
284750372017SENP8 limits aberrant neddylation of NEDD8 pathway components to promote cullin-RING ubiquitin ligase function.21
256559322015NEDDylation promotes endothelial dysfunction: a role for HDAC2.18
264034032015PAPILLARY THYROID CANCER IS CHARACTERIZED BY ALTERED EXPRESSION OF GENES INVOLVED IN THE SUMOYLATION PROCESS.11
256559322015NEDDylation promotes endothelial dysfunction: a role for HDAC2.18
264034032015PAPILLARY THYROID CANCER IS CHARACTERIZED BY ALTERED EXPRESSION OF GENES INVOLVED IN THE SUMOYLATION PROCESS.11
230010412013NEDDylation controls the target specificity of E2F1 and apoptosis induction.25
232093202013Central role for endothelial human deneddylase-1/SENP8 in fine-tuning the vascular inflammatory response.31
234089082013Control of multicellular development by the physically interacting deneddylases DEN1/DenA and COP9 signalosome.25
230010412013NEDDylation controls the target specificity of E2F1 and apoptosis induction.25
232093202013Central role for endothelial human deneddylase-1/SENP8 in fine-tuning the vascular inflammatory response.31

Citation

Dessen P

SENP8 (SUMO peptidase family member, NEDD8 specific)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/73118/senp8-(sumo-peptidase-family-member-nedd8-specific)