Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 114132
MIM: 607157
HGNC: 15622
Ensembl: ENSG00000161640
Variants:
dbSNP: 114132
ClinVar: 114132
TCGA: ENSG00000161640
COSMIC: SIGLEC11
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000161640 | ENST00000426296 | H7C2S0 |
| ENSG00000161640 | ENST00000426971 | Q96RL6 |
| ENSG00000161640 | ENST00000447370 | Q96RL6 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Immune System | REACTOME | R-HSA-168256 |
| Adaptive Immune System | REACTOME | R-HSA-1280218 |
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | REACTOME | R-HSA-198933 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 32845322 | 2021 | Human-specific microglial Siglec-11 transcript variant has the potential to affect polysialic acid-mediated brain functions at a distance. | 9 |
| 32845322 | 2021 | Human-specific microglial Siglec-11 transcript variant has the potential to affect polysialic acid-mediated brain functions at a distance. | 9 |
| 28100677 | 2017 | Paired Siglec receptors generate opposite inflammatory responses to a human-specific pathogen. | 37 |
| 28100677 | 2017 | Paired Siglec receptors generate opposite inflammatory responses to a human-specific pathogen. | 37 |
| 21467073 | 2011 | Expression of Siglec-11 by human and chimpanzee ovarian stromal cells, with uniquely human ligands: implications for human ovarian physiology and pathology. | 19 |
| 21467073 | 2011 | Expression of Siglec-11 by human and chimpanzee ovarian stromal cells, with uniquely human ligands: implications for human ovarian physiology and pathology. | 19 |
| 20203208 | 2010 | Alleviation of neurotoxicity by microglial human Siglec-11. | 87 |
| 20237496 | 2010 | New genetic associations detected in a host response study to hepatitis B vaccine. | 37 |
| 20203208 | 2010 | Alleviation of neurotoxicity by microglial human Siglec-11. | 87 |
| 20237496 | 2010 | New genetic associations detected in a host response study to hepatitis B vaccine. | 37 |
| 18629938 | 2008 | SIGLEC16 encodes a DAP12-associated receptor expressed in macrophages that evolved from its inhibitory counterpart SIGLEC11 and has functional and non-functional alleles in humans. | 51 |
| 18629938 | 2008 | SIGLEC16 encodes a DAP12-associated receptor expressed in macrophages that evolved from its inhibitory counterpart SIGLEC11 and has functional and non-functional alleles in humans. | 51 |
| 16151003 | 2005 | A human-specific gene in microglia. | 39 |
| 16151003 | 2005 | A human-specific gene in microglia. | 39 |
| 11986327 | 2002 | Cloning and characterization of human Siglec-11. A recently evolved signaling molecule that can interact with SHP-1 and SHP-2 and is expressed by tissue macrophages, including brain microglia. | 77 |
Citation
Dessen P
SIGLEC11 (sialic acid binding Ig like lectin 11)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/73243/siglec11-(sialic-acid-binding-ig-like-lectin-11)
