Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 100049587
MIM: 618132
HGNC: 32926
Ensembl: ENSG00000254415
Variants:
dbSNP: 100049587
ClinVar: 100049587
TCGA: ENSG00000254415
COSMIC: SIGLEC14
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000254415 | ENST00000360844 | Q08ET2 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Immune System | REACTOME | R-HSA-168256 |
| Innate Immune System | REACTOME | R-HSA-168249 |
| DAP12 interactions | REACTOME | R-HSA-2172127 |
| Neutrophil degranulation | REACTOME | R-HSA-6798695 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36109518 | 2022 | Pangenomic analysis of Chinese gastric cancer. | 7 |
| 36109518 | 2022 | Pangenomic analysis of Chinese gastric cancer. | 7 |
| 34208838 | 2021 | Analysis of Genetic Variants Associated with Levels of Immune Modulating Proteins for Impact on Alzheimer's Disease Risk Reveal a Potential Role for SIGLEC14. | 5 |
| 34208838 | 2021 | Analysis of Genetic Variants Associated with Levels of Immune Modulating Proteins for Impact on Alzheimer's Disease Risk Reveal a Potential Role for SIGLEC14. | 5 |
| 31805552 | 2020 | Siglec-14 Enhances NLRP3-Inflammasome Activation in Macrophages. | 25 |
| 31805552 | 2020 | Siglec-14 Enhances NLRP3-Inflammasome Activation in Macrophages. | 25 |
| 30377253 | 2018 | Soluble Siglec-14 glycan-recognition protein is generated by alternative splicing and suppresses myeloid inflammatory responses. | 10 |
| 30377253 | 2018 | Soluble Siglec-14 glycan-recognition protein is generated by alternative splicing and suppresses myeloid inflammatory responses. | 10 |
| 28005267 | 2017 | Human gingiva transcriptome during wound healing. | 14 |
| 28454648 | 2017 | The SIGLEC14 null allele is associated with Mycobacterium tuberculosis- and BCG-induced clinical and immunologic outcomes. | 12 |
| 28005267 | 2017 | Human gingiva transcriptome during wound healing. | 14 |
| 28454648 | 2017 | The SIGLEC14 null allele is associated with Mycobacterium tuberculosis- and BCG-induced clinical and immunologic outcomes. | 12 |
| 26459514 | 2015 | Immunomodulatory activity of extracellular Hsp70 mediated via paired receptors Siglec-5 and Siglec-14. | 48 |
| 26459514 | 2015 | Immunomodulatory activity of extracellular Hsp70 mediated via paired receptors Siglec-5 and Siglec-14. | 48 |
| 24799499 | 2014 | Siglec-5 and Siglec-14 are polymorphic paired receptors that modulate neutrophil and amnion signaling responses to group B Streptococcus. | 98 |
Citation
Dessen P
SIGLEC14 (sialic acid binding Ig like lectin 14)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/73244/siglec14-(sialic-acid-binding-ig-like-lectin-14)
