SLC15A2 (solute carrier family 15 member 2)

2014-11-01  

Identity

HGNC
LOCATION
3q13.33
LOCUSID
ALIAS
PEPT2

Other Information

Locus ID:

NCBI: 6565
MIM: 602339
HGNC: 10921
Ensembl: ENSG00000163406

Variants:

dbSNP: 6565
ClinVar: 6565
TCGA: ENSG00000163406
COSMIC: SLC15A2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163406ENST00000295605Q16348
ENSG00000163406ENST00000469013C9IZ38
ENSG00000163406ENST00000489711Q16348

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of inorganic cations/anions and amino acids/oligopeptidesREACTOMER-HSA-425393
Proton/oligopeptide cotransportersREACTOMER-HSA-427975

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA444447Carcinoma, HepatocellularDiseaseClinicalAnnotationassociatedPD
PA7000sorafenibChemicalClinicalAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
317574252020Alternate expression of PEPT1 and PEPT2 in epidermal differentiation is required for NOD2 immune responses by bacteria-derived muramyl dipeptide.1
317574252020Alternate expression of PEPT1 and PEPT2 in epidermal differentiation is required for NOD2 immune responses by bacteria-derived muramyl dipeptide.1
310736932019The proton-coupled oligopeptide transporters PEPT2, PHT1 and PHT2 mediate the uptake of carnosine in glioblastoma cells.17
310736932019The proton-coupled oligopeptide transporters PEPT2, PHT1 and PHT2 mediate the uptake of carnosine in glioblastoma cells.17
292340732017Identification of two novel genes SLC15A2 and SLCO1B3 associated with maintenance dose variability of warfarin in a Chinese population.3
292340732017Identification of two novel genes SLC15A2 and SLCO1B3 associated with maintenance dose variability of warfarin in a Chinese population.3
272164632016H(+)/peptide transporter (PEPT2) is expressed in human epidermal keratinocytes and is involved in skin oligopeptide transport.2
272164632016H(+)/peptide transporter (PEPT2) is expressed in human epidermal keratinocytes and is involved in skin oligopeptide transport.2
255145832015δ-Aminolevulinic acid dehydratase single nucleotide polymorphism 2 (ALAD2) and peptide transporter 2*2 haplotype (hPEPT2*2) differently influence neurobehavior in low-level lead exposed children.15
259658252015SLC15A2 genomic variation is associated with the extraordinary response of sorafenib treatment: whole-genome analysis in patients with hepatocellular carcinoma.21
261688632015Functional Expression of PEPT2 in the Human Distal Lung Epithelial Cell Line NCl-H441.2
255145832015δ-Aminolevulinic acid dehydratase single nucleotide polymorphism 2 (ALAD2) and peptide transporter 2*2 haplotype (hPEPT2*2) differently influence neurobehavior in low-level lead exposed children.15
259658252015SLC15A2 genomic variation is associated with the extraordinary response of sorafenib treatment: whole-genome analysis in patients with hepatocellular carcinoma.21
261688632015Functional Expression of PEPT2 in the Human Distal Lung Epithelial Cell Line NCl-H441.2
255311002014Downregulation of peptide transporters PEPT1 and PEPT2 by oxidative stress responsive kinase OSR1.2

Citation

Dessen P

SLC15A2 (solute carrier family 15 member 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/73284/slc15a2-(solute-carrier-family-15-member-2)