SLC18A3 (solute carrier family 18 member A3)

2014-11-01  

Identity

HGNC
LOCATION
10q11.23
LOCUSID
ALIAS
CMS21,VACHT

Other Information

Locus ID:

NCBI: 6572
MIM: 600336
HGNC: 10936
Ensembl: ENSG00000187714

Variants:

dbSNP: 6572
ClinVar: 6572
TCGA: ENSG00000187714
COSMIC: SLC18A3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000187714ENST00000374115Q16572

Expression (GTEx)

0
1
2
3
4
5

Pathways

PathwaySourceExternal ID
Cholinergic synapseKEGGhsa04725
Synaptic vesicle cycleKEGGko04721
Synaptic vesicle cycleKEGGhsa04721
Neuronal SystemREACTOMER-HSA-112316
Transmission across Chemical SynapsesREACTOMER-HSA-112315
Neurotransmitter Release CycleREACTOMER-HSA-112310
Acetylcholine Neurotransmitter Release CycleREACTOMER-HSA-264642
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Clathrin-mediated endocytosisREACTOMER-HSA-8856828
Cargo recognition for clathrin-mediated endocytosisREACTOMER-HSA-8856825

References

Pubmed IDYearTitleCitations
334620162021Variants of SLC18A3 leading to congenital myasthenic syndrome in two children with varying presentations.5
336386392021Striatal and cerebellar vesicular acetylcholine transporter expression is disrupted in human DYT1 dystonia.11
339403172021Expression of VAChT and 5-HT in Ulcerative colitis dendritic cells.15
349439892021Phenotypical and Myopathological Consequences of Compound Heterozygous Missense and Nonsense Variants in SLC18A3.1
334620162021Variants of SLC18A3 leading to congenital myasthenic syndrome in two children with varying presentations.5
336386392021Striatal and cerebellar vesicular acetylcholine transporter expression is disrupted in human DYT1 dystonia.11
339403172021Expression of VAChT and 5-HT in Ulcerative colitis dendritic cells.15
349439892021Phenotypical and Myopathological Consequences of Compound Heterozygous Missense and Nonsense Variants in SLC18A3.1
307208842019Cholinergic system changes of falls and freezing of gait in Parkinson's disease.72
310592092019SLC18A3 variants lead to fetal akinesia deformation sequence early in pregnancy.5
307208842019Cholinergic system changes of falls and freezing of gait in Parkinson's disease.72
310592092019SLC18A3 variants lead to fetal akinesia deformation sequence early in pregnancy.5
302559362018Regional vesicular acetylcholine transporter distribution in human brain: A [(18) F]fluoroethoxybenzovesamicol positron emission tomography study.25
302559362018Regional vesicular acetylcholine transporter distribution in human brain: A [(18) F]fluoroethoxybenzovesamicol positron emission tomography study.25
281883022017Vesicular acetylcholine transporter defect underlies devastating congenital myasthenia syndrome.11

Citation

Dessen P

SLC18A3 (solute carrier family 18 member A3)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/73309/slc18a3-(solute-carrier-family-18-member-a3)