SLC1A4 (solute carrier family 1 member 4)

2014-11-01  

Identity

HGNC
LOCATION
2p14
LOCUSID
ALIAS
ASCT1,SATT,SPATCCM
FUSION GENES

Other Information

Locus ID:

NCBI: 6509
MIM: 600229
HGNC: 10942
Ensembl: ENSG00000115902

Variants:

dbSNP: 6509
ClinVar: 6509
TCGA: ENSG00000115902
COSMIC: SLC1A4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115902ENST00000234256P43007
ENSG00000115902ENST00000531327P43007

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of inorganic cations/anions and amino acids/oligopeptidesREACTOMER-HSA-425393
Amino acid transport across the plasma membraneREACTOMER-HSA-352230

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
356055072022A rare cause of microcephaly, thin corpus callosum and refractory epilepsy due to a novel SLC1A4 gene mutation.4
356055072022A rare cause of microcephaly, thin corpus callosum and refractory epilepsy due to a novel SLC1A4 gene mutation.4
279092462017Retromer- and WASH-dependent sorting of nutrient transporters requires a multivalent interaction network with ANKRD50.35
288076742017Phenylglycine analogs are inhibitors of the neutral amino acid transporters ASCT1 and ASCT2 and enhance NMDA receptor-mediated LTP in rat visual cortex slices.13
279092462017Retromer- and WASH-dependent sorting of nutrient transporters requires a multivalent interaction network with ANKRD50.35
288076742017Phenylglycine analogs are inhibitors of the neutral amino acid transporters ASCT1 and ASCT2 and enhance NMDA receptor-mediated LTP in rat visual cortex slices.13
271932182016Novel European SLC1A4 variant: infantile spasms and population ancestry analysis.12
271932182016Novel European SLC1A4 variant: infantile spasms and population ancestry analysis.12
259309712015A homozygous mutation in SLC1A4 in siblings with severe intellectual disability and microcephaly.20
260417622015Mutations in SLC1A4, encoding the brain serine transporter, are associated with developmental delay, microcephaly and hypomyelination.29
261384992015SLC1A4 mutations cause a novel disorder of intellectual disability, progressive microcephaly, spasticity and thin corpus callosum.28
259309712015A homozygous mutation in SLC1A4 in siblings with severe intellectual disability and microcephaly.20
260417622015Mutations in SLC1A4, encoding the brain serine transporter, are associated with developmental delay, microcephaly and hypomyelination.29
261384992015SLC1A4 mutations cause a novel disorder of intellectual disability, progressive microcephaly, spasticity and thin corpus callosum.28
248081812014Na+ interactions with the neutral amino acid transporter ASCT1.10

Citation

Dessen P

SLC1A4 (solute carrier family 1 member 4)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/73311/slc1a4-(solute-carrier-family-1-member-4)