Identity
HGNC
LOCATION
11q13.1
LOCUSID
ALIAS
OAT4,hOAT4
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 55867
MIM: 607097
HGNC: 18120
Ensembl: ENSG00000168065
Variants:
dbSNP: 55867
ClinVar: 55867
TCGA: ENSG00000168065
COSMIC: SLC22A11
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA443434 | Arthritis, Rheumatoid | Disease | ClinicalAnnotation | associated | PD | 26086825 | |
| PA444318 | Gout | Disease | VariantAnnotation | not associated | PD | 29341237 | |
| PA448320 | allopurinol | Chemical | VariantAnnotation | not associated | PD | 29341237 | |
| PA450428 | methotrexate | Chemical | ClinicalAnnotation | associated | PD | 26086825 | |
| PA451954 | zidovudine | Chemical | Pathway | associated | 22960662 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38222853 | 2024 | Examining the Association of Rare Allelic Variants in Urate Transporters SLC22A11, SLC22A13, and SLC17A1 with Hyperuricemia and Gout. | 1 |
| 38222853 | 2024 | Examining the Association of Rare Allelic Variants in Urate Transporters SLC22A11, SLC22A13, and SLC17A1 with Hyperuricemia and Gout. | 1 |
| 36436016 | 2023 | Perfluoroalkyl substances (PFASs) are substrates of the renal human organic anion transporter 4 (OAT4). | 6 |
| 37487877 | 2023 | The regulation of human organic anion transporter 4 by insulin-like growth factor 1 and protein kinase B signaling. | 1 |
| 36436016 | 2023 | Perfluoroalkyl substances (PFASs) are substrates of the renal human organic anion transporter 4 (OAT4). | 6 |
| 37487877 | 2023 | The regulation of human organic anion transporter 4 by insulin-like growth factor 1 and protein kinase B signaling. | 1 |
| 32363570 | 2020 | Multifaceted genome-wide study identifies novel regulatory loci in SLC22A11 and ZNF45 for body mass index in Indians. | 6 |
| 32363570 | 2020 | Multifaceted genome-wide study identifies novel regulatory loci in SLC22A11 and ZNF45 for body mass index in Indians. | 6 |
| 26740304 | 2016 | Serum- and glucocorticoid-inducible kinase SGK2 regulates human organic anion transporters 4 via ubiquitin ligase Nedd4-2. | 15 |
| 26902266 | 2016 | Genome wide association study of uric acid in Indian population and interaction of identified variants with Type 2 diabetes. | 15 |
| 26740304 | 2016 | Serum- and glucocorticoid-inducible kinase SGK2 regulates human organic anion transporters 4 via ubiquitin ligase Nedd4-2. | 15 |
| 26902266 | 2016 | Genome wide association study of uric acid in Indian population and interaction of identified variants with Type 2 diabetes. | 15 |
| 25919187 | 2015 | Role of OAT4 in Uptake of Estriol Precursor 16α-Hydroxydehydroepiandrosterone Sulfate Into Human Placental Syncytiotrophoblasts From Fetus. | 9 |
| 26303760 | 2015 | Organic anion transporter 4 (OAT 4) modifies placental transfer of perfluorinated alkyl acids PFOS and PFOA in human placental ex vivo perfusion system. | 17 |
| 25919187 | 2015 | Role of OAT4 in Uptake of Estriol Precursor 16α-Hydroxydehydroepiandrosterone Sulfate Into Human Placental Syncytiotrophoblasts From Fetus. | 9 |
Citation
Dessen P
SLC22A11 (solute carrier family 22 member 11)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/73315/slc22a11-(solute-carrier-family-22-member-11)
