SLC27A1 (solute carrier family 27 member 1)

2014-11-01  

Identity

HGNC
LOCATION
19p13.11
LOCUSID
ALIAS
ACSVL5,FATP,FATP-1,FATP1
FUSION GENES

Other Information

Locus ID:

NCBI: 376497
MIM: 600691
HGNC: 10995
Ensembl: ENSG00000130304

Variants:

dbSNP: 376497
ClinVar: 376497
TCGA: ENSG00000130304
COSMIC: SLC27A1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000130304ENST00000252595Q6PCB7
ENSG00000130304ENST00000598424Q6PCB7
ENSG00000130304ENST00000599380M0QXY2
ENSG00000130304ENST00000599965M0QZC9
ENSG00000130304ENST00000600277B7Z225
ENSG00000130304ENST00000600297B7Z225

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
PPAR signaling pathwayKEGGko03320
PPAR signaling pathwayKEGGhsa03320
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of vitamins, nucleosides, and related moleculesREACTOMER-HSA-425397
Transport of fatty acidsREACTOMER-HSA-804914
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)REACTOMER-HSA-400206
PPARA activates gene expressionREACTOMER-HSA-1989781
Insulin resistanceKEGGhsa04931

References

Pubmed IDYearTitleCitations
334866522021The role of FATP1 in lipid accumulation: a review.13
334866522021The role of FATP1 in lipid accumulation: a review.13
306748742019PPARα and PPARγ activation attenuates total free fatty acid and triglyceride accumulation in macrophages via the inhibition of Fatp1 expression.21
310913382019Amyloid beta(25-35) impairs docosahexaenoic acid efflux by down-regulating fatty acid transport protein 1 (FATP1/SLC27A1) protein expression in human brain capillary endothelial cells.10
315759072019Unraveling FATP1, regulated by ER-β, as a targeted breast cancer innovative therapy.14
306748742019PPARα and PPARγ activation attenuates total free fatty acid and triglyceride accumulation in macrophages via the inhibition of Fatp1 expression.21
310913382019Amyloid beta(25-35) impairs docosahexaenoic acid efflux by down-regulating fatty acid transport protein 1 (FATP1/SLC27A1) protein expression in human brain capillary endothelial cells.10
315759072019Unraveling FATP1, regulated by ER-β, as a targeted breast cancer innovative therapy.14
301995452018Physiological and pathological roles of FATP-mediated lipid droplets in Drosophila and mice retina.29
301995452018Physiological and pathological roles of FATP-mediated lipid droplets in Drosophila and mice retina.29
268676812016Neonatal phthalate ester exposure induced placental MTs, FATP1 and HFABP mRNA expression in two districts of southeast China.12
268676812016Neonatal phthalate ester exposure induced placental MTs, FATP1 and HFABP mRNA expression in two districts of southeast China.12
241205742014Fatty acid transporters in skin development, function and disease.31
241205742014Fatty acid transporters in skin development, function and disease.31
209657182011Genetic variability of the fatty acid synthase pathway is not associated with prostate cancer risk in the European Prospective Investigation on Cancer (EPIC).4

Citation

Dessen P

SLC27A1 (solute carrier family 27 member 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/73378/slc27a1-(solute-carrier-family-27-member-1)