SLC30A6 (solute carrier family 30 member 6)

2014-11-01  

Identity

HGNC
LOCATION
2p22.3
LOCUSID
ALIAS
MST103,MSTP103,ZNT6
FUSION GENES

Other Information

Locus ID:

NCBI: 55676
MIM: 611148
HGNC: 19305
Ensembl: ENSG00000152683

Variants:

dbSNP: 55676
ClinVar: 55676
TCGA: ENSG00000152683
COSMIC: SLC30A6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000152683ENST00000282587Q6NXT4
ENSG00000152683ENST00000357055Q6NXT4
ENSG00000152683ENST00000379343Q6NXT4
ENSG00000152683ENST00000406369B5MCR8
ENSG00000152683ENST00000435660Q6NXT4
ENSG00000152683ENST00000440718C9JZR9
ENSG00000152683ENST00000449777F8WEL5
ENSG00000152683ENST00000454324F8WCU3
ENSG00000152683ENST00000457724F8WD78

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Peptide hormone metabolismREACTOMER-HSA-2980736
Insulin processingREACTOMER-HSA-264876
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsREACTOMER-HSA-425366
Metal ion SLC transportersREACTOMER-HSA-425410
Zinc transportersREACTOMER-HSA-435354
Zinc efflux and compartmentalization by the SLC30 familyREACTOMER-HSA-435368

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
336316102021Increased expression of zinc transporter ZIP4, ZIP11, ZnT1, and ZnT6 predicts poor prognosis in pancreatic cancer.17
336316102021Increased expression of zinc transporter ZIP4, ZIP11, ZnT1, and ZnT6 predicts poor prognosis in pancreatic cancer.17
277581242017A genetic variant within SLC30A6 has a protective role in the severity of rheumatoid arthritis.3
277581242017A genetic variant within SLC30A6 has a protective role in the severity of rheumatoid arthritis.3
276614182016Zinc transporters protein level in postmortem brain of depressed subjects and suicide victims.11
276614182016Zinc transporters protein level in postmortem brain of depressed subjects and suicide victims.11
252842862015Zinc transporters ZnT3 and ZnT6 are downregulated in the spinal cords of patients with sporadic amyotrophic lateral sclerosis.22
252842862015Zinc transporters ZnT3 and ZnT6 are downregulated in the spinal cords of patients with sporadic amyotrophic lateral sclerosis.22
223496852012Zinc transporter mRNA levels in Alzheimer's disease postmortem brain.22
223496852012Zinc transporter mRNA levels in Alzheimer's disease postmortem brain.22
193713532010Alterations of zinc transporter proteins ZnT-1, ZnT-4 and ZnT-6 in preclinical Alzheimer's disease brain.45
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.20
193713532010Alterations of zinc transporter proteins ZnT-1, ZnT-4 and ZnT-6 in preclinical Alzheimer's disease brain.45
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.20
197590142009Demonstration and characterization of the heterodimerization of ZnT5 and ZnT6 in the early secretory pathway.53

Citation

Dessen P

SLC30A6 (solute carrier family 30 member 6)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/73391/slc30a6-(solute-carrier-family-30-member-6)