SLC35A1 (solute carrier family 35 member A1)

2014-11-01  

Identity

HGNC
LOCATION
6q15
LOCUSID
ALIAS
CDG2F,CMPST,CST,hCST
FUSION GENES

Other Information

Locus ID:

NCBI: 10559
MIM: 605634
HGNC: 11021
Ensembl: ENSG00000164414

Variants:

dbSNP: 10559
ClinVar: 10559
TCGA: ENSG00000164414
COSMIC: SLC35A1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164414ENST00000369552P78382
ENSG00000164414ENST00000369556P78382
ENSG00000164414ENST00000369557Q5W1L7
ENSG00000164414ENST00000622775A0A087WVM1

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent proteinREACTOMER-HSA-446193
Synthesis of substrates in N-glycan biosythesisREACTOMER-HSA-446219
Sialic acid metabolismREACTOMER-HSA-4085001
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of vitamins, nucleosides, and related moleculesREACTOMER-HSA-425397
Transport of nucleotide sugarsREACTOMER-HSA-727802

References

Pubmed IDYearTitleCitations
323035572021Slc35a1 deficiency causes thrombocytopenia due to impaired megakaryocytopoiesis and excessive platelet clearance in the liver.17
340153302021The promiscuous binding pocket of SLC35A1 ensures redundant transport of CDP-ribitol to the Golgi.6
340696982021Knockout of the CMP-Sialic Acid Transporter SLC35A1 in Human Cell Lines Increases Transduction Efficiency of Adeno-Associated Virus 9: Implications for Gene Therapy Potency Assays.3
343847822021A three-pocket model for substrate coordination and selectivity by the nucleotide sugar transporters SLC35A1 and SLC35A2.2
323035572021Slc35a1 deficiency causes thrombocytopenia due to impaired megakaryocytopoiesis and excessive platelet clearance in the liver.17
340153302021The promiscuous binding pocket of SLC35A1 ensures redundant transport of CDP-ribitol to the Golgi.6
340696982021Knockout of the CMP-Sialic Acid Transporter SLC35A1 in Human Cell Lines Increases Transduction Efficiency of Adeno-Associated Virus 9: Implications for Gene Therapy Potency Assays.3
343847822021A three-pocket model for substrate coordination and selectivity by the nucleotide sugar transporters SLC35A1 and SLC35A2.2
333967462020Novel Insights into Selected Disease-Causing Mutations within the SLC35A1 Gene Encoding the CMP-Sialic Acid Transporter.4
333967462020Novel Insights into Selected Disease-Causing Mutations within the SLC35A1 Gene Encoding the CMP-Sialic Acid Transporter.4
301156592018A mutation in the gene coding for the sialic acid transporter SLC35A1 is required for platelet life span but not proplatelet formation.25
301156592018A mutation in the gene coding for the sialic acid transporter SLC35A1 is required for platelet life span but not proplatelet formation.25
288568332017Encephalopathy caused by novel mutations in the CMP-sialic acid transporter, SLC35A1.15
288568332017Encephalopathy caused by novel mutations in the CMP-sialic acid transporter, SLC35A1.15
273874292016A functional splice variant of the human Golgi CMP-sialic acid transporter.2

Citation

Dessen P

SLC35A1 (solute carrier family 35 member A1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/73397/slc35a1-(solute-carrier-family-35-member-a1)