SLC38A5 (solute carrier family 38 member 5)

2014-11-01  

Identity

HGNC
LOCATION
Xp11.23
LOCUSID
ALIAS
JM24,SN2,SNAT5,pp7194
FUSION GENES

Other Information

Locus ID:

NCBI: 92745
MIM: 300649
HGNC: 18070
Ensembl: ENSG00000017483

Variants:

dbSNP: 92745
ClinVar: 92745
TCGA: ENSG00000017483
COSMIC: SLC38A5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000017483ENST00000413668C9JHH7
ENSG00000017483ENST00000416711C9JMY2
ENSG00000017483ENST00000429543C9JJU1
ENSG00000017483ENST00000440085C9JNK4
ENSG00000017483ENST00000441948C9JWG4
ENSG00000017483ENST00000488083C9JJU1
ENSG00000017483ENST00000494034A0A087WZF9
ENSG00000017483ENST00000595796Q8WUX1
ENSG00000017483ENST00000595796A0A024QYY0
ENSG00000017483ENST00000619100Q8WUX1
ENSG00000017483ENST00000620913Q8WUX1
ENSG00000017483ENST00000620913A0A024QYY0
ENSG00000017483ENST00000622196A0A087X1I6

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
GABAergic synapseKEGGko04727
GABAergic synapseKEGGhsa04727
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of inorganic cations/anions and amino acids/oligopeptidesREACTOMER-HSA-425393
Amino acid transport across the plasma membraneREACTOMER-HSA-352230

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
374584332023The SLC38A5/SNAT5 amino acid transporter: from pathophysiology to pro-cancer roles in the tumor microenvironment.3
375312552023SLC38A5 aggravates DC-mediated psoriasiform skin inflammation via potentiating lysosomal acidification.2
378030432023Amino acid transporter SLC38A5 is a tumor promoter and a novel therapeutic target for pancreatic cancer.4
378873532023SLC38A5 Modulates Ferroptosis to Overcome Gemcitabine Resistance in Pancreatic Cancer.3
374584332023The SLC38A5/SNAT5 amino acid transporter: from pathophysiology to pro-cancer roles in the tumor microenvironment.3
375312552023SLC38A5 aggravates DC-mediated psoriasiform skin inflammation via potentiating lysosomal acidification.2
378030432023Amino acid transporter SLC38A5 is a tumor promoter and a novel therapeutic target for pancreatic cancer.4
378873532023SLC38A5 Modulates Ferroptosis to Overcome Gemcitabine Resistance in Pancreatic Cancer.3
364542142022Amino acid transporter SLC38A5 regulates developmental and pathological retinal angiogenesis.7
364542142022Amino acid transporter SLC38A5 regulates developmental and pathological retinal angiogenesis.7
347045972021Expression and function of SLC38A5, an amino acid-coupled Na+/H+ exchanger, in triple-negative breast cancer and its relevance to macropinocytosis.15
347045972021Expression and function of SLC38A5, an amino acid-coupled Na+/H+ exchanger, in triple-negative breast cancer and its relevance to macropinocytosis.15
294996432018Identification of placental nutrient transporters associated with intrauterine growth restriction and pre-eclampsia.38
294996432018Identification of placental nutrient transporters associated with intrauterine growth restriction and pre-eclampsia.38
173332822007Loss of SLC38A5 and FTSJ1 at Xp11.23 in three brothers with non-syndromic mental retardation due to a microdeletion in an unstable genomic region.19

Citation

Dessen P

SLC38A5 (solute carrier family 38 member 5)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/73425/slc38a5-(solute-carrier-family-38-member-5)