SLC41A1 (solute carrier family 41 member 1)

2014-11-01  

Identity

HGNC
LOCATION
1q32.1
LOCUSID
ALIAS
MgtE
FUSION GENES

Other Information

Locus ID:

NCBI: 254428
MIM: 610801
HGNC: 19429
Ensembl: ENSG00000133065

Variants:

dbSNP: 254428
ClinVar: 254428
TCGA: ENSG00000133065
COSMIC: SLC41A1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000133065ENST00000367137Q8IVJ1
ENSG00000133065ENST00000367137B2RMP2

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsREACTOMER-HSA-425366
Metal ion SLC transportersREACTOMER-HSA-425410

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
351635272022Alzheimer's Disease-Associated SNP rs708727 in SLC41A1 May Increase Risk for Parkinson's Disease: Report from Enlarged Slovak Study.3
351635272022Alzheimer's Disease-Associated SNP rs708727 in SLC41A1 May Increase Risk for Parkinson's Disease: Report from Enlarged Slovak Study.3
282227672017Knockdown of SLC41A1 magnesium transporter promotes mineralization and attenuates magnesium inhibition during osteogenesis of mesenchymal stromal cells.12
282227672017Knockdown of SLC41A1 magnesium transporter promotes mineralization and attenuates magnesium inhibition during osteogenesis of mesenchymal stromal cells.12
276120222016Genetic Analysis of the ZNF512B, SLC41A1, and ALDH2 Polymorphisms in Parkinson's Disease in the Iranian Population.7
276120222016Genetic Analysis of the ZNF512B, SLC41A1, and ALDH2 Polymorphisms in Parkinson's Disease in the Iranian Population.7
263081522015Genetic analysis of SLC41A1 in Chinese Parkinson's disease patients.9
263550012015Insulin Modulates the Na+/Mg2+ Exchanger SLC41A1 and Influences Mg2+ Efflux from Intracellular Stores in Transgenic HEK293 Cells.14
263081522015Genetic analysis of SLC41A1 in Chinese Parkinson's disease patients.9
263550012015Insulin Modulates the Na+/Mg2+ Exchanger SLC41A1 and Influences Mg2+ Efflux from Intracellular Stores in Transgenic HEK293 Cells.14
246614662014Variant R244H in Na+/Mg2+ exchanger SLC41A1 in Taiwanese Parkinson's disease is associated with loss of Mg2+ efflux function.8
246614662014Variant R244H in Na+/Mg2+ exchanger SLC41A1 in Taiwanese Parkinson's disease is associated with loss of Mg2+ efflux function.8
236618052013Mutation of the Mg2+ transporter SLC41A1 results in a nephronophthisis-like phenotype.28
238231792013Nature of SLC41A1 complexes: report on the split-ubiquitin yeast two hybrid assay.2
238447282013SLC41A1 is the only magnesium responsive gene significantly overexpressed in placentas of preeclamptic women.8

Citation

Dessen P

SLC41A1 (solute carrier family 41 member 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/73440/slc41a1-(solute-carrier-family-41-member-1)