SLC43A2 (solute carrier family 43 member 2)

2014-11-01  

Identity

HGNC
LOCATION
17p13.3
LOCUSID
ALIAS
LAT4
FUSION GENES

Other Information

Locus ID:

NCBI: 124935
MIM: 610791
HGNC: 23087
Ensembl: ENSG00000167703

Variants:

dbSNP: 124935
ClinVar: 124935
TCGA: ENSG00000167703
COSMIC: SLC43A2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000167703ENST00000301335Q8N370
ENSG00000167703ENST00000412517Q8N370
ENSG00000167703ENST00000571376I3L4V3
ENSG00000167703ENST00000571650Q8N370
ENSG00000167703ENST00000572801I3L4J2
ENSG00000167703ENST00000576721I3L3E3

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of inorganic cations/anions and amino acids/oligopeptidesREACTOMER-HSA-425393
Amino acid transport across the plasma membraneREACTOMER-HSA-352230

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
330772722021Plasma citrulline correlates with basolateral amino acid transporter LAT4 expression in human small intestine.5
330772722021Plasma citrulline correlates with basolateral amino acid transporter LAT4 expression in human small intestine.5
328794892020Cancer SLC43A2 alters T cell methionine metabolism and histone methylation.226
328794892020Cancer SLC43A2 alters T cell methionine metabolism and histone methylation.226
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.15
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.15
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.105
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.105
156593992005Identification of LAT4, a novel amino acid transporter with system L activity.91
156593992005Identification of LAT4, a novel amino acid transporter with system L activity.91

Citation

Dessen P

SLC43A2 (solute carrier family 43 member 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/73443/slc43a2-(solute-carrier-family-43-member-2)