SLC5A7 (solute carrier family 5 member 7)

2014-11-01  

Identity

HGNC
LOCATION
2q12.3
LOCUSID
ALIAS
CHT,CHT1,CMS20,HMN7A

Other Information

Locus ID:

NCBI: 60482
MIM: 608761
HGNC: 14025
Ensembl: ENSG00000115665

Variants:

dbSNP: 60482
ClinVar: 60482
TCGA: ENSG00000115665
COSMIC: SLC5A7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115665ENST00000264047Q9GZV3
ENSG00000115665ENST00000409059Q9GZV3

Expression (GTEx)

0
1
2
3
4

Pathways

PathwaySourceExternal ID
Cholinergic synapseKEGGhsa04725
Choline metabolism in cancerKEGGhsa05231
Choline metabolism in cancerKEGGko05231
Neuronal SystemREACTOMER-HSA-112316
Transmission across Chemical SynapsesREACTOMER-HSA-112315
Neurotransmitter Release CycleREACTOMER-HSA-112310
Acetylcholine Neurotransmitter Release CycleREACTOMER-HSA-264642
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsREACTOMER-HSA-425366

References

Pubmed IDYearTitleCitations
388866332024Genetic analysis of a family affected by congenital myasthenic syndrome due to a Novel mutation in the SLC5A7 gene.0
388866332024Genetic analysis of a family affected by congenital myasthenic syndrome due to a Novel mutation in the SLC5A7 gene.0
345625202022Choline-induced SLC5A7 impairs colorectal cancer growth by stabilizing p53 protein.6
358589182022Targeted demethylation of the SLC5A7 promotor inhibits colorectal cancer progression.1
345625202022Choline-induced SLC5A7 impairs colorectal cancer growth by stabilizing p53 protein.6
358589182022Targeted demethylation of the SLC5A7 promotor inhibits colorectal cancer progression.1
312991402019The novel p.Ser263Phe mutation in the human high-affinity choline transporter 1 (CHT1/SLC5A7) causes a lethal form of fetal akinesia syndrome.7
312991402019The novel p.Ser263Phe mutation in the human high-affinity choline transporter 1 (CHT1/SLC5A7) causes a lethal form of fetal akinesia syndrome.7
297826452018Confirmation of SLC5A7-related distal hereditary motor neuropathy 7 in a family outside Wales.3
300052792018Polymorphic variation in the SLC5A7 gene influences infant autonomic reactivity and self-regulation: A neurobiological model for ANS stress responsivity and infant temperament.3
297826452018Confirmation of SLC5A7-related distal hereditary motor neuropathy 7 in a family outside Wales.3
300052792018Polymorphic variation in the SLC5A7 gene influences infant autonomic reactivity and self-regulation: A neurobiological model for ANS stress responsivity and infant temperament.3
288308232017Lack of association between SLC5A7 polymorphisms and Tourette syndrome in a Chinese Han population.1
290883542017Choline transporter mutations in severe congenital myasthenic syndrome disrupt transporter localization.8
288308232017Lack of association between SLC5A7 polymorphisms and Tourette syndrome in a Chinese Han population.1

Citation

Dessen P

SLC5A7 (solute carrier family 5 member 7)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/73465/slc5a7-(solute-carrier-family-5-member-7)