Identity
HGNC
LOCATION
11p15.1
LOCUSID
ALIAS
GLYT-2,GLYT2,HKPX3,NET1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 9152
MIM: 604159
HGNC: 11051
Ensembl: ENSG00000165970
Variants:
dbSNP: 9152
ClinVar: 9152
TCGA: ENSG00000165970
COSMIC: SLC6A5
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000165970 | ENST00000298923 | J3KNC4 |
| ENSG00000165970 | ENST00000525748 | Q9Y345 |
Expression (GTEx)
Pathways
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA447216 | Schizophrenia | Disease | ClinicalAnnotation | associated | PD | 20859245 | |
| PA449841 | haloperidol | Chemical | ClinicalAnnotation, MultilinkAnnotation | associated | PD | 20859245, 27023437 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 33450225 | 2021 | The allosteric inhibition of glycine transporter 2 by bioactive lipid analgesics is controlled by penetration into a deep lipid cavity. | 5 |
| 33450225 | 2021 | The allosteric inhibition of glycine transporter 2 by bioactive lipid analgesics is controlled by penetration into a deep lipid cavity. | 5 |
| 32191428 | 2020 | Photoswitchable ORG25543 Congener Enables Optical Control of Glycine Transporter 2. | 5 |
| 32191428 | 2020 | Photoswitchable ORG25543 Congener Enables Optical Control of Glycine Transporter 2. | 5 |
| 29859229 | 2019 | Hyperekplexia-associated mutations in the neuronal glycine transporter 2. | 5 |
| 29859229 | 2019 | Hyperekplexia-associated mutations in the neuronal glycine transporter 2. | 5 |
| 25480793 | 2015 | Molecular basis of the dominant negative effect of a glycine transporter 2 mutation associated with hyperekplexia. | 16 |
| 25480793 | 2015 | Molecular basis of the dominant negative effect of a glycine transporter 2 mutation associated with hyperekplexia. | 16 |
| 23484054 | 2013 | Constitutive endocytosis and turnover of the neuronal glycine transporter GlyT2 is dependent on ubiquitination of a C-terminal lysine cluster. | 16 |
| 23962079 | 2013 | Reversible inhibition of the glycine transporter GlyT2 circumvents acute toxicity while preserving efficacy in the treatment of pain. | 22 |
| 23484054 | 2013 | Constitutive endocytosis and turnover of the neuronal glycine transporter GlyT2 is dependent on ubiquitination of a C-terminal lysine cluster. | 16 |
| 23962079 | 2013 | Reversible inhibition of the glycine transporter GlyT2 circumvents acute toxicity while preserving efficacy in the treatment of pain. | 22 |
| 22700964 | 2012 | Mutations in the GlyT2 gene (SLC6A5) are a second major cause of startle disease. | 40 |
| 22753417 | 2012 | A novel dominant hyperekplexia mutation Y705C alters trafficking and biochemical properties of the presynaptic glycine transporter GlyT2. | 22 |
| 22700964 | 2012 | Mutations in the GlyT2 gene (SLC6A5) are a second major cause of startle disease. | 40 |
Citation
Dessen P
SLC6A5 (solute carrier family 6 member 5)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/73477/slc6a5-(solute-carrier-family-6-member-5)
