SLC8A3 (solute carrier family 8 member A3)

2014-11-01  

Identity

HGNC
LOCATION
14q24.2
LOCUSID
ALIAS
NCX3
FUSION GENES

Other Information

Locus ID:

NCBI: 6547
MIM: 607991
HGNC: 11070
Ensembl: ENSG00000100678

Variants:

dbSNP: 6547
ClinVar: 6547
TCGA: ENSG00000100678
COSMIC: SLC8A3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100678ENST00000216568P57103
ENSG00000100678ENST00000356921P57103
ENSG00000100678ENST00000357887P57103
ENSG00000100678ENST00000381269P57103
ENSG00000100678ENST00000394330P57103
ENSG00000100678ENST00000494208P57103
ENSG00000100678ENST00000528359P57103
ENSG00000100678ENST00000533541F2Z391
ENSG00000100678ENST00000534137P57103

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9

Pathways

PathwaySourceExternal ID
Calcium signaling pathwayKEGGko04020
Olfactory transductionKEGGko04740
Calcium signaling pathwayKEGGhsa04020
Olfactory transductionKEGGhsa04740
Protein digestion and absorptionKEGGko04974
Protein digestion and absorptionKEGGhsa04974
cGMP-PKG signaling pathwayKEGGhsa04022
cGMP-PKG signaling pathwayKEGGko04022
HemostasisREACTOMER-HSA-109582
Platelet homeostasisREACTOMER-HSA-418346
Platelet calcium homeostasisREACTOMER-HSA-418360
Reduction of cytosolic Ca++ levelsREACTOMER-HSA-418359
Muscle contractionREACTOMER-HSA-397014
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of inorganic cations/anions and amino acids/oligopeptidesREACTOMER-HSA-425393
Sodium/Calcium exchangersREACTOMER-HSA-425561
Cardiac conductionREACTOMER-HSA-5576891
Ion homeostasisREACTOMER-HSA-5578775
Apelin signaling pathwayKEGGhsa04371

References

Pubmed IDYearTitleCitations
357050782022Sodium-calcium exchanger-3 regulates pain "wind-up": From human psychophysics to spinal mechanisms.6
357050782022Sodium-calcium exchanger-3 regulates pain "wind-up": From human psychophysics to spinal mechanisms.6
341270212021The downregulation of NCXs is positively correlated with the prognosis of stage II-IV colon cancer.3
341270212021The downregulation of NCXs is positively correlated with the prognosis of stage II-IV colon cancer.3
295263222018Glycosylation controls sodium-calcium exchanger 3 sub-cellular localization during cell cycle.4
295263222018Glycosylation controls sodium-calcium exchanger 3 sub-cellular localization during cell cycle.4
282335672017Differential regulation of the Na(+)-Ca(2+) exchanger 3 (NCX3) by protein kinase PKC and PKA.2
295948572017Structure-Dynamic Coupling Through Ca(2+)-Binding Regulatory Domains of Mammalian NCX Isoform/Splice Variants.6
282335672017Differential regulation of the Na(+)-Ca(2+) exchanger 3 (NCX3) by protein kinase PKC and PKA.2
295948572017Structure-Dynamic Coupling Through Ca(2+)-Binding Regulatory Domains of Mammalian NCX Isoform/Splice Variants.6
269834532016A genome-wide association study identifies SLC8A3 as a susceptibility locus for ACPA-positive rheumatoid arthritis.10
269834532016A genome-wide association study identifies SLC8A3 as a susceptibility locus for ACPA-positive rheumatoid arthritis.10
239196772014Calpain cleavage and inactivation of the sodium calcium exchanger-3 occur downstream of Aβ in Alzheimer's disease.17
239196772014Calpain cleavage and inactivation of the sodium calcium exchanger-3 occur downstream of Aβ in Alzheimer's disease.17
232248832013NCX as a key player in the neuroprotection exerted by ischemic preconditioning and postconditioning.20

Citation

Dessen P

SLC8A3 (solute carrier family 8 member A3)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/73493/slc8a3-(solute-carrier-family-8-member-a3)