SLCO4C1 (solute carrier organic anion transporter family member 4C1)

2014-11-01  

Identity

HGNC
LOCATION
5q21.1
LOCUSID
ALIAS
OATP-H,OATP-M1,OATP4C1,OATPX,PRO2176,SLC21A20

Other Information

Locus ID:

NCBI: 353189
MIM: 609013
HGNC: 23612
Ensembl: ENSG00000173930

Variants:

dbSNP: 353189
ClinVar: 353189
TCGA: ENSG00000173930
COSMIC: SLCO4C1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000173930ENST00000310954Q6ZQN7

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of vitamins, nucleosides, and related moleculesREACTOMER-HSA-425397
Transport of organic anionsREACTOMER-HSA-879518
Neutrophil degranulationREACTOMER-HSA-6798695

References

Pubmed IDYearTitleCitations
340486682021Role of OATP4C1 in Renal Handling of Remdesivir and its Nucleoside Analog GS-441524: The First Approved Drug for Patients with COVID-19.2
340486682021Role of OATP4C1 in Renal Handling of Remdesivir and its Nucleoside Analog GS-441524: The First Approved Drug for Patients with COVID-19.2
320202312020Knockdown of SLCO4C1 inhibits cell proliferation and metastasis in endometrial cancer through inactivating the PI3K/Akt signaling pathway.11
320202312020Knockdown of SLCO4C1 inhibits cell proliferation and metastasis in endometrial cancer through inactivating the PI3K/Akt signaling pathway.11
312888502019SLCO4C1 promoter methylation is a potential biomarker for prognosis associated with biochemical recurrence-free survival after radical prostatectomy.7
312888502019SLCO4C1 promoter methylation is a potential biomarker for prognosis associated with biochemical recurrence-free survival after radical prostatectomy.7
206108912010Transport of estrone 3-sulfate mediated by organic anion transporter OATP4C1: estrone 3-sulfate binds to the different recognition site for digoxin in OATP4C1.12
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.15
206914132010Genetic variation in solute carrier genes is associated with preeclampsia.4
206108912010Transport of estrone 3-sulfate mediated by organic anion transporter OATP4C1: estrone 3-sulfate binds to the different recognition site for digoxin in OATP4C1.12
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.15
206914132010Genetic variation in solute carrier genes is associated with preeclampsia.4
191972492009Steroid biosynthesis and renal excretion in human essential hypertension: association with blood pressure and endogenous ouabain.19
198758112009SLCO4C1 transporter eliminates uremic toxins and attenuates hypertension and renal inflammation.47
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.105

Citation

Dessen P

SLCO4C1 (solute carrier organic anion transporter family member 4C1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/73508/slco4c1-(solute-carrier-organic-anion-transporter-family-member-4c1)