B3GALT5 (beta-1,3-galactosyltransferase 5)

2003-06-01  

Identity

HGNC
B3GALT5
LOCATION
21q22.2
LOCUSID
10317
ALIAS
B3GalT-V,B3GalTx,B3T5,GLCT5,beta-1

Other Information

Locus ID:

NCBI: 10317
MIM: 604066
HGNC: 920
Ensembl: ENSG00000183778

Variants:

dbSNP: 10317
ClinVar: 10317
TCGA: ENSG00000183778
COSMIC: B3GALT5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000183778ENST00000343118Q9Y2C3
ENSG00000183778ENST00000380618Q9Y2C3
ENSG00000183778ENST00000380620Q9Y2C3
ENSG00000183778ENST00000398714A0A0A0MS93
ENSG00000183778ENST00000615480Q9Y2C3

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glycosphingolipid biosynthesis - lacto and neolacto seriesKEGGko00601
Glycosphingolipid biosynthesis - lacto and neolacto seriesKEGGhsa00601
Glycosphingolipid biosynthesis - globo and isoglobo seriesKEGGhsa00603
Metabolic pathwaysKEGGhsa01100
Glycosphingolipid biosynthesis, lacto-series, LacCer => Lc4CerKEGGhsa_M00070
Glycosphingolipid biosynthesis, lacto-series, LacCer => Lc4CerKEGGM00070

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
195678912009Genetic utility of broadly defined bipolar schizoaffective disorder as a diagnostic concept.38
161128242005Endogenous retrovirus long terminal repeats as ready-to-use mobile promoters: the case of primate beta3GAL-T5.18
204949802010Functional analysis and identification of cis-regulatory elements of human chromosome 21 gene promoters.10
275356142017Unexpected distribution of CA19.9 and other type 1 chain Lewis antigens in normal and cancer tissues of colon and pancreas: Importance of the detection method and role of glycosyltransferase regulation.7
191365852009Enhanced expression of beta 3-galactosyltransferase 5 activity is sufficient to induce in vivo synthesis of extended type 1 chains on lactosylceramides of selected human colonic carcinoma cell lines.6
192252462009Beta1,3-galactosyltransferases-4/5 are novel tumor markers for gynecological cancers.6
220015592012DNA methylation and histone modifications modulate the β1,3 galactosyltransferase β3Gal-T5 native promoter in cancer cells.6
241288902014Transcriptional control of the B3GALT5 gene by a retroviral promoter and methylation of distant regulatory elements.6
288834152017High expression FUT1 and B3GALT5 is an independent predictor of postoperative recurrence and survival in hepatocellular carcinoma.5
308087452019Signaling pathway of globo-series glycosphingolipids and β1,3-galactosyltransferase V (β3GalT5) in breast cancer.4

Citation

Dessen P

B3GALT5 (beta-1,3-galactosyltransferase 5)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/737/b3galt5-(beta-1-3-galactosyltransferase-5)