Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 57537
MIM: 606284
HGNC: 16698
Ensembl: ENSG00000184985
Variants:
dbSNP: 57537
ClinVar: 57537
TCGA: ENSG00000184985
COSMIC: SORCS2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000184985 | ENST00000329016 | B5MED8 |
| ENSG00000184985 | ENST00000505529 | H0Y9I2 |
| ENSG00000184985 | ENST00000507866 | Q96PQ0 |
Expression (GTEx)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA10251 | atazanavir | Chemical | ClinicalAnnotation | associated | PK | 31562781 | |
| PA447230 | HIV Infections | Disease | ClinicalAnnotation | associated | PK | 31562781 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 34741697 | 2023 | Loss of SORCS2 is Associated with Neuronal DNA Double-Strand Breaks. | 4 |
| 37507021 | 2023 | Alternative splicing regulates adaptor protein binding, trafficking, and activity of the Vps10p domain receptor SorCS2 in neuronal development. | 0 |
| 34741697 | 2023 | Loss of SORCS2 is Associated with Neuronal DNA Double-Strand Breaks. | 4 |
| 37507021 | 2023 | Alternative splicing regulates adaptor protein binding, trafficking, and activity of the Vps10p domain receptor SorCS2 in neuronal development. | 0 |
| 31562781 | 2020 | Association of Pharmacogenetic Markers With Atazanavir Exposure in HIV-Infected Women. | 0 |
| 31562781 | 2020 | Association of Pharmacogenetic Markers With Atazanavir Exposure in HIV-Infected Women. | 0 |
| 30840898 | 2019 | SorCS2 Controls Functional Expression of Amino Acid Transporter EAAT3 and Protects Neurons from Oxidative Stress and Epilepsy-Induced Pathology. | 20 |
| 30840898 | 2019 | SorCS2 Controls Functional Expression of Amino Acid Transporter EAAT3 and Protects Neurons from Oxidative Stress and Epilepsy-Induced Pathology. | 20 |
| 29315502 | 2018 | A Genome-Wide Association Study Identifies a Candidate Gene Associated With Atazanavir Exposure Measured in Hair. | 1 |
| 30252935 | 2018 | Risk Locus Identification Ties Alcohol Withdrawal Symptoms to SORCS2. | 10 |
| 29315502 | 2018 | A Genome-Wide Association Study Identifies a Candidate Gene Associated With Atazanavir Exposure Measured in Hair. | 1 |
| 30252935 | 2018 | Risk Locus Identification Ties Alcohol Withdrawal Symptoms to SORCS2. | 10 |
| 28827148 | 2017 | Hidden Twins: SorCS Neuroreceptors Form Stable Dimers. | 10 |
| 28827148 | 2017 | Hidden Twins: SorCS Neuroreceptors Form Stable Dimers. | 10 |
| 26420026 | 2015 | Sortilin-related receptor CNS expressed 2 (SorCS2) is localized to Bunina bodies in amyotrophic lateral sclerosis. | 5 |
Citation
Dessen P
SORCS2 (sortilin related VPS10 domain containing receptor 2)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/74072/sorcs2-(sortilin-related-vps10-domain-containing-receptor-2)
