Identity
HGNC
LOCATION
2q37.1
LOCUSID
ALIAS
LYSP100,LYSP100-A,LYSP100-B
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 11262
MIM: 608602
HGNC: 17133
Ensembl: ENSG00000079263
Variants:
dbSNP: 11262
ClinVar: 11262
TCGA: ENSG00000079263
COSMIC: SP140
RNA/Proteins
Expression (GTEx)
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 35952671 | 2022 | Epigenetic reader SP140 loss of function drives Crohn's disease due to uncontrolled macrophage topoisomerases. | 12 |
| 36130593 | 2022 | Immune chromatin reader SP140 regulates microbiota and risk for inflammatory bowel disease. | 5 |
| 36600652 | 2022 | SP140 inhibits STAT1 signaling, induces IFN-γ in tumor-associated macrophages, and is a predictive biomarker of immunotherapy response. | 7 |
| 35952671 | 2022 | Epigenetic reader SP140 loss of function drives Crohn's disease due to uncontrolled macrophage topoisomerases. | 12 |
| 36130593 | 2022 | Immune chromatin reader SP140 regulates microbiota and risk for inflammatory bowel disease. | 5 |
| 36600652 | 2022 | SP140 inhibits STAT1 signaling, induces IFN-γ in tumor-associated macrophages, and is a predictive biomarker of immunotherapy response. | 7 |
| 30465816 | 2019 | Sp140 is a multi-SUMO-1 target and its PHD finger promotes SUMOylation of the adjacent Bromodomain. | 10 |
| 30465816 | 2019 | Sp140 is a multi-SUMO-1 target and its PHD finger promotes SUMOylation of the adjacent Bromodomain. | 10 |
| 30102396 | 2018 | SP140 regulates the expression of immune-related genes associated with multiple sclerosis and other autoimmune diseases by NF-κB inhibition. | 18 |
| 30102396 | 2018 | SP140 regulates the expression of immune-related genes associated with multiple sclerosis and other autoimmune diseases by NF-κB inhibition. | 18 |
| 26888452 | 2016 | Whole Genome DNA Methylation Analysis of Obstructive Sleep Apnea: IL1R2, NPR2, AR, SP140 Methylation and Clinical Phenotype. | 27 |
| 26888452 | 2016 | Whole Genome DNA Methylation Analysis of Obstructive Sleep Apnea: IL1R2, NPR2, AR, SP140 Methylation and Clinical Phenotype. | 27 |
| 26152201 | 2015 | A functional variant that affects exon-skipping and protein expression of SP140 as genetic mechanism predisposing to multiple sclerosis. | 26 |
| 26152201 | 2015 | A functional variant that affects exon-skipping and protein expression of SP140 as genetic mechanism predisposing to multiple sclerosis. | 26 |
| 20332261 | 2010 | Genetic susceptibility variants for chronic lymphocytic leukemia. | 18 |
Citation
Dessen P
SP140 (SP140 nuclear body protein)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/74086/sp140-(sp140-nuclear-body-protein)
