Identity
HGNC
LOCATION
12q24.31
LOCUSID
ALIAS
IMP2,MDHV1887,PRO4332,PSH1,PSL4
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 121665
MIM: 608240
HGNC: 30424
Ensembl: ENSG00000157837
Variants:
dbSNP: 121665
ClinVar: 121665
TCGA: ENSG00000157837
COSMIC: SPPL3
RNA/Proteins
Expression (GTEx)
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 35279766 | 2022 | N-terminome analyses underscore the prevalence of SPPL3-mediated intramembrane proteolysis among Golgi-resident enzymes and its role in Golgi enzyme secretion. | 4 |
| 35279766 | 2022 | N-terminome analyses underscore the prevalence of SPPL3-mediated intramembrane proteolysis among Golgi-resident enzymes and its role in Golgi enzyme secretion. | 4 |
| 33271119 | 2021 | The SPPL3-Defined Glycosphingolipid Repertoire Orchestrates HLA Class I-Mediated Immune Responses. | 31 |
| 34303967 | 2021 | SPPL3-dependent downregulation of the synthesis of (neo)lacto-series glycosphingolipid is required for the staining of cell surface CD59. | 2 |
| 33271119 | 2021 | The SPPL3-Defined Glycosphingolipid Repertoire Orchestrates HLA Class I-Mediated Immune Responses. | 31 |
| 34303967 | 2021 | SPPL3-dependent downregulation of the synthesis of (neo)lacto-series glycosphingolipid is required for the staining of cell surface CD59. | 2 |
| 28292959 | 2017 | Multiepitope tissue analysis reveals SPPL3-mediated ADAM10 activation as a key step in the transformation of melanocytes. | 13 |
| 28292959 | 2017 | Multiepitope tissue analysis reveals SPPL3-mediated ADAM10 activation as a key step in the transformation of melanocytes. | 13 |
| 25384971 | 2015 | A protease-independent function for SPPL3 in NFAT activation. | 15 |
| 25827571 | 2015 | Secretome analysis identifies novel signal Peptide peptidase-like 3 (Sppl3) substrates and reveals a role of Sppl3 in multiple Golgi glycosylation pathways. | 37 |
| 25827571 | 2015 | Secretome analysis identifies novel signal Peptide peptidase-like 3 (Sppl3) substrates and reveals a role of Sppl3 in multiple Golgi glycosylation pathways. | 37 |
| 25384971 | 2015 | A protease-independent function for SPPL3 in NFAT activation. | 15 |
| 25827571 | 2015 | Secretome analysis identifies novel signal Peptide peptidase-like 3 (Sppl3) substrates and reveals a role of Sppl3 in multiple Golgi glycosylation pathways. | 37 |
| 25827571 | 2015 | Secretome analysis identifies novel signal Peptide peptidase-like 3 (Sppl3) substrates and reveals a role of Sppl3 in multiple Golgi glycosylation pathways. | 37 |
| 25354954 | 2014 | Shedding of glycan-modifying enzymes by signal peptide peptidase-like 3 (SPPL3) regulates cellular N-glycosylation. | 41 |
Citation
Dessen P
SPPL3 (signal peptide peptidase like 3)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/74199/meetings/new-content/
