SPPL3 (signal peptide peptidase like 3)

2014-11-01  

Identity

HGNC
LOCATION
12q24.31
LOCUSID
ALIAS
IMP2,MDHV1887,PRO4332,PSH1,PSL4
FUSION GENES

Other Information

Locus ID:

NCBI: 121665
MIM: 608240
HGNC: 30424
Ensembl: ENSG00000157837

Variants:

dbSNP: 121665
ClinVar: 121665
TCGA: ENSG00000157837
COSMIC: SPPL3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000157837ENST00000353487Q8TCT6
ENSG00000157837ENST00000536996F5H7J2
ENSG00000157837ENST00000540091F5H4Y6
ENSG00000157837ENST00000543181F5H4L1
ENSG00000157837ENST00000543608F5H6I1
ENSG00000157837ENST00000543854F5H2A2

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
153855472004Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins.40
159986422005Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3.31
168738902006Intramembrane proteolytic cleavage by human signal peptide peptidase like 3 and malaria signal peptide peptidase.21
253549542014Shedding of glycan-modifying enzymes by signal peptide peptidase-like 3 (SPPL3) regulates cellular N-glycosylation.19
253549542014Shedding of glycan-modifying enzymes by signal peptide peptidase-like 3 (SPPL3) regulates cellular N-glycosylation.19
231328522012Foamy virus envelope protein is a substrate for signal peptide peptidase-like 3 (SPPL3).18
258275712015Secretome analysis identifies novel signal Peptide peptidase-like 3 (Sppl3) substrates and reveals a role of Sppl3 in multiple Golgi glycosylation pathways.16
258275712015Secretome analysis identifies novel signal Peptide peptidase-like 3 (Sppl3) substrates and reveals a role of Sppl3 in multiple Golgi glycosylation pathways.16
253849712015A protease-independent function for SPPL3 in NFAT activation.7
282929592017Multiepitope tissue analysis reveals SPPL3-mediated ADAM10 activation as a key step in the transformation of melanocytes.6

Citation

Dessen P

SPPL3 (signal peptide peptidase like 3)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/74199/sppl3-(signal-peptide-peptidase-like-3)