SRSF11 (serine and arginine rich splicing factor 11)

2014-11-01  

Identity

HGNC
LOCATION
1p31.1
LOCUSID
ALIAS
NET2,SFRS11,dJ677H15.2,p54
FUSION GENES

Other Information

Locus ID:

NCBI: 9295
MIM: 602010
HGNC: 10782
Ensembl: ENSG00000116754

Variants:

dbSNP: 9295
ClinVar: 9295
TCGA: ENSG00000116754
COSMIC: SRSF11

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000116754ENST00000370949Q5T757
ENSG00000116754ENST00000370950Q05519
ENSG00000116754ENST00000370951Q05519
ENSG00000116754ENST00000395136Q5T760
ENSG00000116754ENST00000473950S4R3C4
ENSG00000116754ENST00000475204B4DWT1

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase II TranscriptionREACTOMER-HSA-73857
RNA Polymerase II Transcription TerminationREACTOMER-HSA-73856
Cleavage of Growing Transcript in the Termination RegionREACTOMER-HSA-109688
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA SplicingREACTOMER-HSA-72172
mRNA Splicing - Major PathwayREACTOMER-HSA-72163
mRNA 3'-end processingREACTOMER-HSA-72187
Transport of Mature Transcript to CytoplasmREACTOMER-HSA-72202
Transport of Mature mRNA derived from an Intron-Containing TranscriptREACTOMER-HSA-159236

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
370137742023METTL3-mediated downregulation of splicing factor SRSF11 is associated with carcinogenesis and poor survival of cancer patients.1
370137742023METTL3-mediated downregulation of splicing factor SRSF11 is associated with carcinogenesis and poor survival of cancer patients.1
363942062022Alternative splicing of HSPA12A pre-RNA by SRSF11 contributes to metastasis potential of colorectal cancer.5
363942062022Alternative splicing of HSPA12A pre-RNA by SRSF11 contributes to metastasis potential of colorectal cancer.5
246571922014Regulation of gene expression programmes by serine-arginine rich splicing factors.71
246571922014Regulation of gene expression programmes by serine-arginine rich splicing factors.71
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
188320532009Microtubule interfering agents and KSP inhibitors induce the phosphorylation of the nuclear protein p54(nrb), an event linked to G2/M arrest.4
188320532009Microtubule interfering agents and KSP inhibitors induce the phosphorylation of the nuclear protein p54(nrb), an event linked to G2/M arrest.4
169434172006SRp54 (SFRS11), a regulator for tau exon 10 alternative splicing identified by an expression cloning strategy.28
169434172006SRp54 (SFRS11), a regulator for tau exon 10 alternative splicing identified by an expression cloning strategy.28

Citation

Dessen P

SRSF11 (serine and arginine rich splicing factor 11)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/74249/