Identity
HGNC
LOCATION
2p11.2
LOCUSID
ALIAS
GALPHA,MTDPS9,SUCLA1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 8802
MIM: 611224
HGNC: 11449
Ensembl: ENSG00000163541
Variants:
dbSNP: 8802
ClinVar: 8802
TCGA: ENSG00000163541
COSMIC: SUCLG1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000163541 | ENST00000393868 | P53597 |
| ENSG00000163541 | ENST00000442240 | H7C233 |
| ENSG00000163541 | ENST00000651342 | A0A494C0D1 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38649537 | 2024 | SUCLG1 restricts POLRMT succinylation to enhance mitochondrial biogenesis and leukemia progression. | 1 |
| 38649537 | 2024 | SUCLG1 restricts POLRMT succinylation to enhance mitochondrial biogenesis and leukemia progression. | 1 |
| 29217198 | 2018 | Clinical, Molecular, and Computational Analysis in two cases with mitochondrial encephalomyopathy associated with SUCLG1 mutation in a consanguineous family. | 4 |
| 29217198 | 2018 | Clinical, Molecular, and Computational Analysis in two cases with mitochondrial encephalomyopathy associated with SUCLG1 mutation in a consanguineous family. | 4 |
| 26028457 | 2016 | Five novel SUCLG1 mutations in three Chinese patients with succinate-CoA ligase deficiency noticed by mild methylmalonic aciduria. | 6 |
| 26475597 | 2016 | Succinate-CoA ligase deficiency due to mutations in SUCLA2 and SUCLG1: phenotype and genotype correlations in 71 patients. | 35 |
| 27484306 | 2016 | Expanding the phenotypic spectrum of Succinyl-CoA ligase deficiency through functional validation of a new SUCLG1 variant. | 8 |
| 26028457 | 2016 | Five novel SUCLG1 mutations in three Chinese patients with succinate-CoA ligase deficiency noticed by mild methylmalonic aciduria. | 6 |
| 26475597 | 2016 | Succinate-CoA ligase deficiency due to mutations in SUCLA2 and SUCLG1: phenotype and genotype correlations in 71 patients. | 35 |
| 27484306 | 2016 | Expanding the phenotypic spectrum of Succinyl-CoA ligase deficiency through functional validation of a new SUCLG1 variant. | 8 |
| 22980518 | 2012 | Mitochondrial DNA depletion syndrome: new descriptions and the use of citrate synthase as a helpful tool to better characterise the patients. | 14 |
| 22980518 | 2012 | Mitochondrial DNA depletion syndrome: new descriptions and the use of citrate synthase as a helpful tool to better characterise the patients. | 14 |
| 20197121 | 2010 | New SUCLG1 patients expanding the phenotypic spectrum of this rare cause of mild methylmalonic aciduria. | 11 |
| 20227526 | 2010 | Marked mitochondrial DNA depletion associated with a novel SUCLG1 gene mutation resulting in lethal neonatal acidosis, multi-organ failure, and interrupted aortic arch. | 7 |
| 20693550 | 2010 | The severity of phenotype linked to SUCLG1 mutations could be correlated with residual amount of SUCLG1 protein. | 15 |
Citation
Dessen P
SUCLG1 (succinate-CoA ligase GDP/ADP-forming subunit alpha)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/74353/suclg1-(succinate-coa-ligase-gdp-adp-forming-subunit-alpha)
