SZT2 (SZT2 subunit of KICSTOR complex)

2014-11-01  

Identity

HGNC
LOCATION
1p34.2
LOCUSID
ALIAS
C1orf84,DEE18,EIEE18,KIAA0467,KICS1,SZT2A,SZT2B
FUSION GENES

Other Information

Locus ID:

NCBI: 23334
MIM: 615463
HGNC: 29040
Ensembl: ENSG00000198198

Variants:

dbSNP: 23334
ClinVar: 23334
TCGA: ENSG00000198198
COSMIC: SZT2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198198ENST00000372450Q5T011
ENSG00000198198ENST00000406439A0A0C4DG05
ENSG00000198198ENST00000470139A0A1W2PRY5
ENSG00000198198ENST00000562955Q5T011
ENSG00000198198ENST00000634258Q5T011
ENSG00000198198ENST00000639852A0A1W2PQY2

Expression (GTEx)

0
5
10
15
20
25
30

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
381346492024Clinical phenotype and genetic characteristics of SZT2 related diseases: A case report and literature review.0
381346492024Clinical phenotype and genetic characteristics of SZT2 related diseases: A case report and literature review.0
353522052022Genetic analysis of developmental and epileptic encephalopathy caused by novel biallelic SZT2 gene mutations in three Chinese Han infants: a case series and literature review.1
363618812022Induced Pluripotent Stem Cell (iPSC) Lines from a Family with Resistant Epileptic Encephalopathy Caused by Compound Heterozygous Mutations in SZT2 Gene.0
353522052022Genetic analysis of developmental and epileptic encephalopathy caused by novel biallelic SZT2 gene mutations in three Chinese Han infants: a case series and literature review.1
363618812022Induced Pluripotent Stem Cell (iPSC) Lines from a Family with Resistant Epileptic Encephalopathy Caused by Compound Heterozygous Mutations in SZT2 Gene.0
336816502021A novel possible familial cause of epilepsy of infancy with migrating focal seizures related to SZT2 gene variant.3
346856912021The SZT2 Interactome Unravels New Functions of the KICSTOR Complex.6
336816502021A novel possible familial cause of epilepsy of infancy with migrating focal seizures related to SZT2 gene variant.3
346856912021The SZT2 Interactome Unravels New Functions of the KICSTOR Complex.6
324027032020Developmental and epileptic encephalopathy due to SZT2 genomic variants: Emerging features of a syndromic condition.8
324027032020Developmental and epileptic encephalopathy due to SZT2 genomic variants: Emerging features of a syndromic condition.8
313971142019Novel SZT2 mutations in three patients with developmental and epileptic encephalopathies.7
314303542019Constitutive activation of mTORC1 signaling induced by biallelic loss-of-function mutations in SZT2 underlies a discernible neurodevelopmental disease.6
313971142019Novel SZT2 mutations in three patients with developmental and epileptic encephalopathies.7

Citation

Dessen P

SZT2 (SZT2 subunit of KICSTOR complex)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/74446