TAAR6 (trace amine associated receptor 6)

2014-11-01 Affiliation

Identity

HGNC

TAAR6

LOCATION

6q23.2

LOCUSID

319100

ALIAS

TA4,TAR4,TAR6,TRAR4,taR-4,taR-6

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 319100
MIM: 608923
HGNC: 20978
Ensembl: ENSG00000146383

Variants:

dbSNP: 319100
ClinVar: 319100
TCGA: ENSG00000146383
COSMIC: TAAR6

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000146383	ENST00000275198	Q96RI8

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Neuroactive ligand-receptor interaction	KEGG	ko04080
Neuroactive ligand-receptor interaction	KEGG	hsa04080
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
Amine ligand-binding receptors	REACTOME	R-HSA-375280
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (s) signalling events	REACTOME	R-HSA-418555

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA10026	aripiprazole	Chemical	ClinicalAnnotation	associated	PD	19345712
PA10832	corticosteroids	Chemical	ClinicalAnnotation	associated	PD	25919112
PA443450	Asthma	Disease	ClinicalAnnotation	associated	PD	25919112
PA447216	Schizophrenia	Disease	ClinicalAnnotation	associated	PD	19345712

References

Pubmed ID	Year	Title	Citations
36139098	2022	Public Transcriptomic Data Meta-Analysis Demonstrates TAAR6 Expression in the Mental Disorder-Related Brain Areas in Human and Mouse Brain.	3
36139098	2022	Public Transcriptomic Data Meta-Analysis Demonstrates TAAR6 Expression in the Mental Disorder-Related Brain Areas in Human and Mouse Brain.	3
35008636	2021	Search for Structural Basis of Interactions of Biogenic Amines with Human TAAR1 and TAAR6 Receptors.	6
35008636	2021	Search for Structural Basis of Interactions of Biogenic Amines with Human TAAR1 and TAAR6 Receptors.	6
25919112	2015	Association between TAAR6 polymorphisms and airway responsiveness to inhaled corticosteroids in asthmatic patients.	3
25919112	2015	Association between TAAR6 polymorphisms and airway responsiveness to inhaled corticosteroids in asthmatic patients.	3
19582769	2010	Investigation of an epistastic effect between a set of TAAR6 and HSP-70 genes variations and major mood disorders.	4
20493543	2010	TAAR6 variations possibly associated with antidepressant response and suicidal behavior.	6
20493543	2010	TAAR6 variations possibly associated with antidepressant response and suicidal behavior.	6
19582769	2010	Investigation of an epistastic effect between a set of TAAR6 and HSP-70 genes variations and major mood disorders.	4
20493543	2010	TAAR6 variations possibly associated with antidepressant response and suicidal behavior.	6
20493543	2010	TAAR6 variations possibly associated with antidepressant response and suicidal behavior.	6
18973992	2009	The trace amine associated receptor (TAAR6) gene is not associated with schizophrenia in the Irish Case-Control Study of Schizophrenia (ICCSS) sample.	4
18973992	2009	The trace amine associated receptor (TAAR6) gene is not associated with schizophrenia in the Irish Case-Control Study of Schizophrenia (ICCSS) sample.	4
19345712	2009	Influence of TAAR6 polymorphisms on response to aripiprazole.	3

Citation

Dessen P

TAAR6 (trace amine associated receptor 6)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/74452/taar6-(trace-amine-associated-receptor-6)