TAC3 (tachykinin precursor 3)

2014-11-01  

Identity

HGNC
LOCATION
12q13.3
LOCUSID
ALIAS
HH10,LncZBTB39,NK3,NKB,NKNB,PRO1155,ZNEUROK1

Other Information

Locus ID:

NCBI: 6866
MIM: 162330
HGNC: 11521
Ensembl: ENSG00000166863

Variants:

dbSNP: 6866
ClinVar: 6866
TCGA: ENSG00000166863
COSMIC: TAC3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166863ENST00000300108Q9UHF0
ENSG00000166863ENST00000300108A0A024RB47
ENSG00000166863ENST00000357616Q9UHF0
ENSG00000166863ENST00000357616A0A024RB36
ENSG00000166863ENST00000379411Q9UHF0
ENSG00000166863ENST00000379411A0A024RB97
ENSG00000166863ENST00000393867Q9UHF0
ENSG00000166863ENST00000393867A0A024RB36
ENSG00000166863ENST00000415231Q9UHF0
ENSG00000166863ENST00000415231A0A024RB47
ENSG00000166863ENST00000423597Q9UHF0
ENSG00000166863ENST00000423597A0A024RB97
ENSG00000166863ENST00000438756Q9UHF0
ENSG00000166863ENST00000438756A0A024RB36
ENSG00000166863ENST00000441881Q9UHF0
ENSG00000166863ENST00000441881A0A024RB97
ENSG00000166863ENST00000458521Q9UHF0
ENSG00000166863ENST00000458521A0A024RB47
ENSG00000166863ENST00000615887Q9UHF0
ENSG00000166863ENST00000615887A0A024RB47

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
Tachykinin receptors bind tachykininsREACTOMER-HSA-380095
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
364536002023The overexpression of neurokinin B-neurokinin 3 receptor system exerts direct effects on the ovary under PCOS-like conditions to interfere with mitochondrial function.3
364536002023The overexpression of neurokinin B-neurokinin 3 receptor system exerts direct effects on the ovary under PCOS-like conditions to interfere with mitochondrial function.3
351702672022Serum kisspeptin, leptin, neuropeptide Y, and neurokinin B levels in adolescents with polycystic ovary syndrome.5
351702672022Serum kisspeptin, leptin, neuropeptide Y, and neurokinin B levels in adolescents with polycystic ovary syndrome.5
336752112021The role of makorin ring finger protein-3, kisspeptin, and neurokinin B in the physiology of minipuberty.0
336752112021The role of makorin ring finger protein-3, kisspeptin, and neurokinin B in the physiology of minipuberty.0
319527882020Endocytic recycling prevents copper accumulation in astrocytoma cells stimulated with copper-bound neurokinin B.1
319527882020Endocytic recycling prevents copper accumulation in astrocytoma cells stimulated with copper-bound neurokinin B.1
283804862018Neurokinin 3 Receptor Antagonism Reveals Roles for Neurokinin B in the Regulation of Gonadotropin Secretion and Hot Flashes in Postmenopausal Women.18
283804862018Neurokinin 3 Receptor Antagonism Reveals Roles for Neurokinin B in the Regulation of Gonadotropin Secretion and Hot Flashes in Postmenopausal Women.18
280088602017Basal Serum Neurokinin B Levels in Differentiating Idiopathic Central Precocious Puberty from Premature Thelarche.1
280088602017Basal Serum Neurokinin B Levels in Differentiating Idiopathic Central Precocious Puberty from Premature Thelarche.1
275808022016Neurokinin B Exerts Direct Effects on the Ovary to Stimulate Estradiol Production.16
275808022016Neurokinin B Exerts Direct Effects on the Ovary to Stimulate Estradiol Production.16
251535672015Association study of TAC3 and TACR3 gene polymorphisms with idiopathic precocious puberty in Chinese girls.6

Citation

Dessen P

TAC3 (tachykinin precursor 3)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/74455/meetings/tumors-explorer/