TAS1R2 (taste 1 receptor member 2)

2014-11-01  

Identity

HGNC
TAS1R2
LOCATION
1p36.13
LOCUSID
80834
ALIAS
GPR71,T1R2,TR2

Other Information

Locus ID:

NCBI: 80834
MIM: 606226
HGNC: 14905
Ensembl: ENSG00000179002

Variants:

dbSNP: 80834
ClinVar: 80834
TCGA: ENSG00000179002
COSMIC: TAS1R2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000179002ENST00000375371Q8TE23

Expression (GTEx)

0
1
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Taste transductionKEGGko04742
Taste transductionKEGGhsa04742
Carbohydrate digestion and absorptionKEGGko04973
Carbohydrate digestion and absorptionKEGGhsa04973
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class C/3 (Metabotropic glutamate/pheromone receptors)REACTOMER-HSA-420499

References

Pubmed IDYearTitleCitations
378170232023Altered expression levels of TAS1R2 and TAS1R3 genes among SARS-CoV-2 variants of concerns.0
378170232023Altered expression levels of TAS1R2 and TAS1R3 genes among SARS-CoV-2 variants of concerns.0
355104852022Relationship between the TAS2R38 and TAS1R2 polymorphisms and the dental status in obese children.2
360124812022Functional Characterization of the Venus Flytrap Domain of the Human TAS1R2 Sweet Taste Receptor.1
363353092022The rs35874116 single nucleotide polymorphism increases sweet intake and the risk of severe early childhood caries: a case-control study.1
355104852022Relationship between the TAS2R38 and TAS1R2 polymorphisms and the dental status in obese children.2
360124812022Functional Characterization of the Venus Flytrap Domain of the Human TAS1R2 Sweet Taste Receptor.1
363353092022The rs35874116 single nucleotide polymorphism increases sweet intake and the risk of severe early childhood caries: a case-control study.1
326077582021Current Progress in Understanding the Structure and Function of Sweet Taste Receptor.9
336541872021Polymorphic variants in Sweet and Umami taste receptor genes and birthweight.2
345096982021The Ile191Val is a partial loss-of-function variant of the TAS1R2 sweet-taste receptor and is associated with reduced glucose excursions in humans.6
326077582021Current Progress in Understanding the Structure and Function of Sweet Taste Receptor.9
336541872021Polymorphic variants in Sweet and Umami taste receptor genes and birthweight.2
345096982021The Ile191Val is a partial loss-of-function variant of the TAS1R2 sweet-taste receptor and is associated with reduced glucose excursions in humans.6
320180802020Structure-based screening for discovery of sweet compounds.5

Citation

Dessen P

TAS1R2 (taste 1 receptor member 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/74485/tas1r2-(taste-1-receptor-member-2)